ArticleJournal of Alzheimer's disease : JAD2019
Effect of Age on the Protein Profile of Healthy Malay Adults and its Association with Cognitive Function Competency.
Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Article
- Metabolomics Profiling of Age-Associated Metabolites in Malay Population.Oxidative medicine and cellular longevity · 2023Article
- Advances and Utility of the Human Plasma Proteome.Journal of proteome research · 2021Review
- Article
- Using Cross-Cultural Studies to Improve Evidence on Dementia Prevention: Lessons from the Special Issue Sponsored by the International Research Network on Dementia Prevention (IRNDP).Journal of Alzheimer's disease : JAD · 2019Article
- Dementia, Risk, Risk Reduction, and Translation into Practice: An International Research Network for Dementia Prevention (IRNDP) Special Issue.Journal of Alzheimer's disease : JAD · 2019Article
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Authors and funding
14 authors.
Funding
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Abstract
backgroundMany studies on biochemical and psychological variables have aimed to elucidate the association between aging and cognitive function. Demographic differences and protein expression have been reported to play a role in determining the cognitive capability of a population.
objectiveThis study aimed to determine the effect of age on the protein profile of Malay individuals and its association with cognitive competency.
methodsA total of 160 individuals were recruited and grouped accordingly. Cognitive competency of each subject was assessed with several neuropsychological tests. Plasma samples were collected and analyzed with Q Exactive HF Orbitrap. Proteins were identified and quantitated with MaxQuant and further analyzed with Perseus to determine differentially expressed proteins. PANTHER, Reactome, and STRING were applied for bioinformatics output.
resultsOur data showed that the Malay individuals are vulnerable to the deterioration of cognitive function with aging, and most of the proteins were differentially expressed in concordance. Several physiological components and pathways were shown to be involved, giving a hint of a promising interpretation on the induction of aging toward the state of the Malays' cognitive function. Nevertheless, some proteins have shown a considerable interaction with the generated protein network, which provides a direction of focus for further investigation.
conclusionThis study demonstrated notable changes in the expression of several proteins as age increased. These changes provide a promising platform for understanding the biochemical factors affecting cognitive function in the Malay population. The exhibited network of protein-protein interaction suggests the possibility of implementing regulatory intervention in ameliorating Malay cognitive function.
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