ArticleRedox biology2019
Statin treatment, oxidative stress and inflammation in a Danish population.
Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Slowing Thoracic Aortic Aneurysm Growth with Statins: A Meta-Analysis.Current cardiology reviews · 2025Pooled it
- Telehealth and challenges of statin adherence in patients with diabetes: a randomized controlled trial.BMC health services research · 2025Trial
- Prime time for the use of statins in MPNs: from comorbidity drugs to disease-modifying partners.Blood advances · 2026Review
- Investigating the phytotherapeutic efficacy ofFrontiers in pharmacology · 2026Article
- Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity.Cell reports. Medicine · 2025Article
- Statins enhance the efficacy of pegylated interferon-alfa2 in Philadelphia-negative chronic myeloproliferative neoplasms.Blood advances · 2025Article
- Pleiotropic effects between statin intake and inflammation parameters in two distinct population-based studies.Communications medicine · 2025Article
- Association Between Statin Use in the Intensive Care Unit and Delirium in Patients Receiving Mechanical Ventilation: A Cross-Sectional Study.Health science reports · 2025Article
- Association between hyperuricemia and all-cause mortality in people taken Statins: a retrospective cohort study.Frontiers in pharmacology · 2025Article
- Statin treatment for cerebral small vessel disease: A systematic review and meta-analysis of randomized controlled trials.Cerebral circulation - cognition and behavior · 2025Review
- Effects of statins on sarcopenia with focus on mechanistic insights and future perspectives.Frontiers in pharmacology · 2025Review
- Idebenone: Clinical Potential Beyond Neurological Diseases.Drug design, development and therapy · 2025Review
- Chronic Low-Grade Inflammation and Brain Structure in the Middle-Aged and Elderly Adults.Nutrients · 2024Article
- INFLA score: a novel inflammatory marker for assessing cardiometabolic disease risk in obese individuals.Diabetology & metabolic syndrome · 2024Article
- Lipid Oxidation Products and the Risk of Cardiovascular Diseases: Role of Lipoprotein Transport.Antioxidants (Basel, Switzerland) · 2024Review
- Lipids, lipid-modified drug target genes, and the risk of male infertility: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Oxidative Stress-Induced Adverse Effects of Three Statins Following Single or Repetitive Treatments in Mice.Cureus · 2024Article
- Hypothyroid women have persistently higher oxidative stress compared to healthy controls.European thyroid journal · 2023Article
- Revisiting Circulating Extracellular Matrix Fragments as Disease Markers in Myelofibrosis and Related Neoplasms.Cancers · 2023Review
- Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study.The journal of headache and pain · 2023Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile statins may have anti-inflammatory effects, anti-oxidative effects are controversial. We investigated if statin treatment is associated with differences in oxidatively generated nucleotide damage and chronic inflammation, and the relationship between nucleotide damage and chronic inflammation.
methodsWe included 19,795 participants from the Danish General Suburban Population Study. In 3420 participants, we measured urinary 8-oxodG and 8-oxoGuo by liquid chromatography-tandem mass spectrometry as markers of oxidatively generated damage to DNA and RNA, respectively. We used a composite score for chronic inflammation (INFLA score) of hsCRP, WBC, platelet count, and neutrophil granulocyte to lymphocyte ratio. Associations were assessed using multivariate linear regression models.
resultsCompared with non-users, statin users had 4.3-6.0% lower 8-oxodG in three separate models (p < 0.05); there were no differences in 8-oxoGuo. Among participants aged > 60 y, statin users had 11.4% lower 8-oxodG (95%CI: 6.7-15.9%, p
conclusionsOxidatively generated DNA damage and inflammatory burden are lower in statin users compared with non-users. Together, anti-oxidative and anti-inflammatory effects may contribute to the beneficial effects of statins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.