ArticleInternational journal of biological macromolecules2019
Alkali-soluble polysaccharides from mushroom fruiting bodies improve insulin resistance.
Article in International journal of biological macromolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 64 citations in OpenAlex.
- Structural Characterizations and In Vitro Bioactivities of a d‑Fructose-Rich Polysaccharide fromACS omega · 2025Article
- Research advances in fungal polysaccharides: production, extraction, characterization, properties, and their multifaceted applications.Frontiers in cellular and infection microbiology · 2025Review
- Structural Characterization, and Antioxidant, Hypoglycemic and Immunomodulatory Activity of Exopolysaccharide fromMolecules (Basel, Switzerland) · 2024Article
- Antitumor activity of Polygonatum sibiricum polysaccharides.Archives of pharmacal research · 2024Review
- The Effects ofFoods (Basel, Switzerland) · 2024Article
- Predicting the bioactive compounds ofHeliyon · 2024Article
- Antidiabetic Properties of Plant Secondary Metabolites.Metabolites · 2023Review
- Effect ofNutrients · 2022Article
- A Review of Development and Utilization for Edible Fungal Polysaccharides: Extraction, Chemical Characteristics, and Bioactivities.Polymers · 2022Review
- Ginsenoside Compound K Protects against Obesity through Pharmacological Targeting of Glucocorticoid Receptor to Activate Lipophagy and Lipid Metabolism.Pharmaceutics · 2022Article
- Structural characterization of a novel polysaccharide from sweet corncob that inhibits glycosylase in STZ-induced diabetic rats : Structural characterization of a novel polysaccharide.Glycoconjugate journal · 2022Article
- Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment.Pharmaceutics · 2022Review
- Polysaccharides influence human healthFrontiers in nutrition · 2022Review
- Neutral Polysaccharides FromFrontiers in pharmacology · 2022Article
- A Novel Polysaccharide FromFrontiers in nutrition · 2022Article
- Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation.Frontiers in pharmacology · 2022Review
- Mushroom polysaccharides with potential in anti-diabetes: Biological mechanisms, extraction, and future perspectives: A review.Frontiers in nutrition · 2022Review
- Bee Pollen Polysaccharide FromFrontiers in pharmacology · 2021Article
- Herbal formula LLKL ameliorates hyperglycaemia, modulates the gut microbiota and regulates the gut-liver axis in Zucker diabetic fatty rats.Journal of cellular and molecular medicine · 2021Article
- Occurrence and possible roles of polysaccharides in fungi and their influence on the development of new technologies.Carbohydrate polymers · 2020Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Insulin resistance is the main cause of type 2 diabetes. Polysaccharide is one of the main active components in mushrooms. Some mushroom polysaccharides have been reported to have beneficial effects against type 2 diabetes. However, the structural features and mechanisms of polysaccharides with hypoglycemic activity have not been elucidated. In this paper, six alkali-soluble total polysaccharides, six neutral polysaccharides and six acidic polysaccharides were extracted and purified from mushrooms fruiting bodies of different species. The effects of these polysaccharides on improving insulin resistance were compared using high fatty acids and glucose-induced hepatocytes. Among them, the neutral polysaccharide AAMP-N of Armillaria mellea fruiting body showed the most significant activity, indicating that mannogalactoglucan is the main active domain. AAMP-N enhanced insulin sensitivity in vitro. Also AAMP-N lowered blood glucose, and modulated lipid metabolism in db/db mice. In addition, AAMP-N protected damaged pancreatic islets in mice. Our results demonstrated the role of natural polysaccharides from mushrooms in the improvement of insulin sensitivity and lipid metabolism, and provided basis for the development of mushroom polysaccharides as hypoglycemic healthy food.
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