ArticleBrain research2019
Early life stress alters opioid receptor mRNA levels within the nucleus accumbens in a sex-dependent manner.
Article in Brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Puberty Blocker, Leuprolide, Reduces Sex Differences in Rough-and-Tumble Play and Anxiety-like Behavior in Juvenile Rats.Endocrinology · 2024Article
- Brain, behavior, and physiological changes associated with predator stress-An animal model for trauma exposure in adult and neonatal rats.Frontiers in molecular neuroscience · 2024Article
- Delayed estrogen actions diminish food consumption without changing food approach, motor activity, or hypothalamic activation elicited by corticostriatal µ-opioid signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Father's care uniquely influences male neurodevelopment.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Stress-Induced Changes in the Endogenous Opioid System Cause Dysfunction of Pain and Emotion Regulation.International journal of molecular sciences · 2023Review
- Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder.Molecular brain · 2023Article
- Key differences in regulation of opioid receptors localized to presynaptic terminals compared to somas: Relevance for novel therapeutics.Neuropharmacology · 2023Review
- Mu Opioid Receptor Dynamics in Healthy Volunteers with a History of Childhood Maltreatment.Journal of child & adolescent trauma · 2022Article
- Early social isolation stress increases addiction vulnerability to heroin and alters c-Fos expression in the mesocorticolimbic system.Psychopharmacology · 2022Article
- Synergistic consequences of early-life social isolation and chronic stress impact coping and neural mechanisms underlying male prairie vole susceptibility and resilience.Frontiers in behavioral neuroscience · 2022Article
- Kappa Opioid Receptors in the Pathology and Treatment of Major Depressive Disorder.Handbook of experimental pharmacology · 2022Review
- Developmental Trajectories of Anhedonia in Preclinical Models.Current topics in behavioral neurosciences · 2022Article
- Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings.Journal of personalized medicine · 2021Review
- Early life stress during the neonatal period alters social play and Line1 during the juvenile stage of development.Scientific reports · 2021Article
- Sex-dependent effects of chronic stress on reinstatement of palatable food seeking and involvement of dopamine DBehavioural brain research · 2021Article
- The Developmental Origins of Opioid Use Disorder and Its Comorbidities.Frontiers in human neuroscience · 2021Review
- Impact of Early Life Stress on Reward Circuit Function and Regulation.Frontiers in psychiatry · 2021Review
- Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula.Neurobiology of stress · 2020Article
- Co-occurrence of preconception maternal childhood adversity and opioid use during pregnancy: Implications for offspring brain development.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Early life stress (ELS) strongly impacts mental health, but little is known about its interaction with biological sex and postnatal development to influence risk and resilience to psychopathologies. A number of psychiatric disorders, such as social anhedonia and drug addiction, involve dysfunctional opioid signaling; moreover, there is evidence for differential central opioid function in males vs. females. The present study examined opioid receptor gene expression in the nucleus accumbens (NAc) and amygdala of male and female rats subjected to a neonatal predator odor exposure (POE) paradigm to model ELS. Brain tissue was collected at two developmental time points: neonatal and juvenile. Results showed that, following the neonatal POE experience, opioid receptor mRNA levels in the NAc were differentially regulated at the neonatal and juvenile time points. POE downregulated neonatal mu- and kappa-opioid receptor mRNA levels in neonatal females, but upregulated mu- and delta-opioid receptor mRNA levels in juvenile females. Intriguingly, POE had no significant effect on NAc opioid receptor mRNA levels in males at either time point, indicating that the impact of POE on opioid system development is sex-dependent. Finally, POE failed to alter amygdalar opioid receptor gene expression in either sex at either time-point. The spatiotemporally- and sex-specific impact of ELS within the developing brain may confer differential risk or resilience for males and females to develop atypical opioid-regulated behaviors associated with conditions such as depression and addiction.
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