ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Molecular characteristics and virulence gene profiles of Staphylococcus aureus causing bloodstream infection.
Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed.
- Genetic diversity, virulence factors and antimicrobial resistance profiles of S. aureus isolated from raw meat, meat products and veterinary samples of food-producing animals in South African provinces.BMC microbiology · 2026Article
- Phenotypic and Genotypic Characterization ofPathogens (Basel, Switzerland) · 2025Article
- Molecular Epidemiology, Antimicrobial Resistance, and Virulence Profiles ofMicroorganisms · 2025Article
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- Clinical and molecular characteristics of Staphylococcus aureus isolates from patients with COVID-19 in Southwest China.BMC infectious diseases · 2025Article
- HarnessingNanomaterials (Basel, Switzerland) · 2025Article
- Surveillance of Antibiotic Resistance and Molecular Epidemiology ofInfection and drug resistance · 2025Article
- Multidrug-ResistantInfection and drug resistance · 2025Article
- Article
- Potential of Natural Phenolic Compounds as Antimicrobial Agents against Multidrug-ResistantMolecules (Basel, Switzerland) · 2023Article
- Spectrum of Virulence Factors in Clinical Isolates ofJournal of laboratory physicians · 2023Article
- Influence of the COVID-19 pandemic on Staphylococcus aureus bloodstream infection in children, Henan, China.The Journal of infection · 2023Article
- Molecular typing and characterization ofFrontiers in microbiology · 2023Article
- ST7 Becomes One of the Most CommonInfection and drug resistance · 2023Article
- Molecular Epidemiology ofInfection and drug resistance · 2023Article
- Genomic epidemiology and characterisation of penicillin-sensitiveEmerging microbes & infections · 2022Article
- Identification of methicillin-resistantEmerging microbes & infections · 2022Article
- Virulence genes distributed among Staphylococcus aureus causing wound infections and their correlation to antibiotic resistance.BMC infectious diseases · 2022Article
- Genetic Diversity, Antibiotic Resistance, and Virulence Gene Features of Methicillin-ResistantInfection and drug resistance · 2022Article
- Investigation of Virulence Genes of the Predominant Bacteria Associated with Renal Stones and their Correlation with Postoperative Septic Complications.Infection and drug resistance · 2022Article
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7 authors.
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Abstract
backgroundThe rate of methicillin-resistant Staphylococcus aureus (MRSA) among the total of S. aureus isolates decreased to 35.3% in 2017 in China. It is unclear whether the molecular characteristics of S. aureus isolates have changed as the rate decreased.
objectiveThis study aimed to investigate the molecular characteristics and virulence genes profile of S. aureus isolates causing bloodstream infection and analyze the correlation between the prevalence rates of the common sequence types and MRSA.
methodsA total of 112 S. aureus strains from eight hospitals of four cities, including 32 MRSA isolates, were identified and evaluated through multilocus sequence typing, spa typing, and determination of virulence genes.
resultsTwenty-five STs were identified, of which ST5 (21.4%) was the most prevalent, whereas the prevalence of ST239 correlated with the rate of MRSA among all S. aureus isolates. Forty-six spa types were identified, of which t2460 (14.3%) was the most common. clfa, hla, seb, fnbA and hlb were the prevailing virulence genes. 81.3% MRSA and 45.0% methicillin-sensitive S. aureus (MSSA) isolates harbored six or more tested virulence genes. ST5-t2460, seldom noted in bloodborne S. aureus isolates in China, was the most common clone. The prevalence of harboring six or more virulence genes in ST5-t2460 and ST188-t189 were 93.8% and 8.3%, respectively.
conclusionST5-t2460 was the most common clone in S. aureus causing bloodstream infection followed by ST188-t189, which had never been noted in China before. Moreover, ST5-t2460 harbored more virulence genes than ST188-t189, and the prevalence of ST239 clone decreased with the proportion of MRSA among all S. aureus isolates.
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