SynthesisReproductive biology and endocrinology : RB&E2018
Air pollution and female fertility: a systematic review of literature.
Synthesis in Reproductive biology and endocrinology : RB&E, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 7 syntheses or guidelines pooled it, 189 citations in OpenAlex.
- Association between Particulate Matter (PM₂.₅), Nitrogen Dioxide (NO₂), Bisphenol A (BPA), and Phthalates and Infertility Outcomes: A Systematic Review and Meta-Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2026Pooled it
- Silent Harm: How Ambient Air Pollution Threatens Prenatal and Neonatal Health. A Systematic Review.Investigacion y educacion en enfermeria · 2025Pooled it
- Association between ambient air pollution exposure and pregnancy outcomes in women treated with assisted reproductive technology: an updated systematic review and meta-analysis.BMC public health · 2025Pooled it
- Assessment of ovarian dysfunction induced by environmental toxins: a systematic review.Frontiers in public health · 2025Pooled it
- Indoor and outdoor air pollution and couple fecundability: a systematic review.Human reproduction update · 2023Pooled it
- Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models.International journal of environmental research and public health · 2020Pooled it
- Impacts of Outdoor Air Pollution on Human Semen Quality: A Meta-Analysis and Systematic Review.BioMed research international · 2020Pooled it
- Mapping the Global Evidence on Environmental and Climatic Factors Linked to Human Fertility-Related Outcomes: Protocol for a Scoping Review.JMIR research protocols · 2026Article
- Ambient PMEnvironmental epidemiology (Philadelphia, Pa.) · 2026Article
- Infertility and Risk of Congenital Anomalies: A Population-Based Cohort Study.Paediatric and perinatal epidemiology · 2026Article
- Recent advances in sex-specific reproductive microphysiological systems for the systematic evaluation of assisted reproductive technology.Materials today. Bio · 2026Review
- Impact of residential air pollution on in vitro fertilization (IVF) outcomes in New Jersey.Journal of assisted reproduction and genetics · 2026Article
- Early-life programming of hypothalamic circuits by maternal obesity: implications for neuroendocrine disorders.Reviews in endocrine & metabolic disorders · 2026Review
- Associations between Ambient Air Pollution Exposure and Menstrual Cycle Irregularity in Premenopausal Women.Yonsei medical journal · 2026Article
- Association of Ambient Air Pollution and Pregnancy Outcomes Among Women with Assisted Reproductive Technology in Qingdao, China: A Retrospective Cohort Study.Risk management and healthcare policy · 2026Article
- Protecting laboratory air quality and comparing clinical assisted reproductive technology cycle outcomes before, during and after wildfire events: a retrospective cohort study.Frontiers in reproductive health · 2026Article
- Living in a chemical cocktail: real-world mixture exposures and their impact on ovarian function.The Journal of reproduction and development · 2026Review
- Toxic air quality in New York in June 2023 and impact on embryology data: survey of 5 leading infertility centers.Journal of assisted reproduction and genetics · 2025Article
- Long-term exposure to ambient air pollutants and female infertility risk: a population-based cohort study in Taiwan.BMC public health · 2025Article
- In vivo gamete toxicology in the context of in vitro fertilization: a narrative review.F&S reviews · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Air pollution is a cause of concern for human health. For instance, it is associated with an increased risk for cancer, cardiovascular and respiratory disorders. In vitro and in vivo studies suggested that air pollutants could act as endocrine disruptors, promote oxidative stress and exert genotoxic effect. Whether air pollution affects female infertility is under debate. The aim of the present study was to conduct a systematic review of studies that evaluated the impact of air pollution on female infertility. We systematically searched the MEDLINE (PubMed) and SCOPUS databases to identify all relevant studies published before October 2017. No time or language restrictions were adopted, and queries were limited to human studies. We also hand-searched the reference lists of relevant studies to ensure we did not miss pertinent studies. The risk of bias and quality assessment of the studies identified were performed using the Newcastle-Ottawa Scale. Primary outcomes were conception rate after spontaneous intercourse and live birth rate after in vitro fertilization (IVF) procedures. Secondary outcomes were first trimester miscarriage, stillbirths, infertility, number of oocytes and embryo retrieved. Eleven articles were included in the analysis. We found that in the IVF population, nitrogen dioxide and ozone were associated with a reduced live birth rate while particulate matter of 10 mm was associated with increased miscarriage. Furthermore, in the general population, particulate matter of 2.5 mm and between 2.5 and 10 mm were associated with reduced fecundability, whereas sulfur dioxide
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.