Evidence map›Paper›PMID 30594124›Full record

ReviewBMC infectious diseases2018

Find the right sample: A study on the versatility of saliva and urine samples for the diagnosis of emerging viruses.

Matthias Niedrig, Pranav Patel, Ahmed Abd El Wahed, Regina Schädler, Sergio Yactayo

Abstract readReview
In one paragraph

Review in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Comprehensive Review on Viral RNA Extraction Strategies for Enhanced Molecular Diagnostics.Interdisciplinary perspectives on infectious diseases · 2025
    Review
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  16. Molecular Detection ofJournal of clinical microbiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matthias NiedrigRobert Koch Institute, Berlin, Germany. niedrigm@gmx.de.ORCID http://orcid.org/0000-0001-7965-4872
Pranav PatelTIB MOLBIOL Syntheselabor GmbH, Berlin, Germany.
Ahmed Abd El WahedDivision of Microbiology and Animal Hygiene, University of Goettingen, Goettingen, Germany.
Regina SchädlerRobert Koch Institute, Berlin, Germany.
Sergio YactayoControl of Epidemic Diseases (CED), World Health Organization, Geneva, Switzerland.

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundThe emergence of different viral infections during the last decades like dengue, West Nile, SARS, chikungunya, MERS-CoV, Ebola, Zika and Yellow Fever raised some questions on quickness and reliability of laboratory diagnostic tests for verification of suspected cases. Since sampling of blood requires medically trained personal and comprises some risks for the patient as well as for the health care personal, the sampling by non-invasive methods (e.g. saliva and/ or urine) might be a very valuable alternative for investigating a diseased patient. MAIN BODY: To analyse the usefulness of alternative non-invasive samples for the diagnosis of emerging infectious viral diseases, a literature search was performed on PubMed for alternative sampling for these viral infections. In total, 711 papers of potential relevance were found, of which we have included 128 in this review.

conclusionsConsidering the experience using non-invasive sampling for the diagnostic of emerging viral diseases, it seems important to perform an investigation using alternative samples for routine diagnostics. Moreover, during an outbreak situation, evaluation of appropriate sampling and further processing for laboratory analysis on various diagnostic platforms are very crucial. This will help to achieve optimal diagnostic results for a good and reliable case identification.

Indexed as

Specimen HandlingUrine Specimen CollectionBiological Variation, PopulationChikungunya FeverCommunicable Diseases, EmergingDengueDiagnostic Tests, RoutineHumansReproducibility of ResultsSalivaVirus DiseasesZika Virus InfectionDiagnosticsEmerging diseasesSample typeViruses

Identifiers

PMID30594124
PMCPMC6311079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.