ArticlePsychiatry research. Neuroimaging2019
Hypoconnectivity of insular resting-state networks in adolescents with Autism Spectrum Disorder.
Article in Psychiatry research. Neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Self-navigating the "Island of Reil": a systematic review of real-time fMRI neurofeedback training of insula activity.Translational psychiatry · 2025Pooled it
- Alterations in self-related brain networks in autism spectrum disorder: a systematic review of functional and structural magnetic resonance imaging studies.Psychoradiology · 2026Review
- Changes in regional homogeneity of the social brain in individuals with autism spectrum disorder after social skills training.Frontiers in psychiatry · 2026Article
- Salience Network in Autism: preliminary results on functional connectivity analysis in resting state.European archives of psychiatry and clinical neuroscience · 2025Article
- Insular functional connectivity in autistic and non-autistic development.Biological psychology · 2025Article
- Dynamic functional adaptations during touch observation in autism: connectivity strength is linked to attitudes towards social touch and social responsiveness.Molecular autism · 2025Article
- Relationship Between Interoception and Autistic Traits: A Resting-State Functional Connectivity Study.Journal of autism and developmental disorders · 2024Article
- Neurochemical differences in core regions of the autistic brain: a multivoxelScientific reports · 2024Article
- Social intelligence mediates the protective role of resting-state brain activity in the social cognition network against social anxiety.Psychoradiology · 2024Article
- Connectivity differences between inferior frontal gyrus and mentalizing network in autism as compared to developmental coordination disorder and non-autistic youth.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Individuals with Autistic Traits Exhibit Heightened Alexithymia But Intact Interoceptive-Exteroceptive Sensory Integration.Journal of autism and developmental disorders · 2022Article
- Multidimensional Interoception and Autistic Traits Across life Stages: Evidence From a Novel Eye-tracking Task.Journal of autism and developmental disorders · 2022Article
- The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder.Nutrients · 2021Review
- Perceived friendship and binge drinking in young adults: A study of the Human Connectome Project data.Drug and alcohol dependence · 2021Article
- Differences in subcortico-cortical interactions identified from connectome and microcircuit models in autism.Nature communications · 2021Article
- Underconnectivity Between Visual and Salience Networks and Links With Sensory Abnormalities in Autism Spectrum Disorders.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
- Electroencephalographic Correlate of Mexican Spanish Emotional Speech Processing in Autism Spectrum Disorder: To a Social Story and Robot-Based Intervention.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Autism Spectrum Disorder (ASD) is characterized by deficits in social interaction and communication. The anterior insula (AI) participates in emotional salience detection; and the posterior insula (PI) participates in sensorimotor integration and response selection. Meta-analyses have noted insula-based aberrant connectivity within ASD. Given the observed social impairments in ASD and the role of the insula in social information processing (SIP), investigating functional organization of this structure in ASD is important. We investigated differences in resting-state functional connectivity (RSFC) using fMRI in male youths with (N=13; mean=14.6 years; range: 10.2-18.0 years) and without ASD (N=17; mean=14.5 years; range: 10.0-17.5 years). With seed-based FC measures, we compared RSFC in insular networks. Hypoconnectivity was observed in ASD (AI-superior frontal gyrus (SFG); AI-thalamus; PI-inferior parietal lobule (IPL); PI-fusiform gyrus (FG); PI-lentiform nucleus/putamen). Using the Social Communication Questionnaire (SCQ) to assess social functioning, regression analyses yielded negative correlations between SCQ scores and RSFC (AI-SFG; AI-thalamus; PI-FG; PI-IPL). Given the insula's connections to limbic regions, and its role in integrating external sensory stimuli with internal states, atypical activity in this structure may be associated with social deficits characterizing ASD. Our results suggest further investigation of the insula's role in SIP across a continuum of social abilities is needed.
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Registered trials
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