ArticleJournal of psychiatric research2019
Brain network functional connectivity and cognitive performance in major depressive disorder.
Article in Journal of psychiatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neurocognitive deficits in depression: a systematic review of cognitive impairment in the acute and remitted state.European archives of psychiatry and clinical neuroscience · 2023Pooled it
- Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure.Frontiers in cardiovascular medicine · 2021Pooled it
- Exploring the impact of cognitive profiles on the response to magnetic seizure therapy and electroconvulsive therapy.Molecular psychiatry · 2026Article
- The diagnostic validity of central symptoms for major depressive disorder in adults with attention-deficit/hyperactivity disorder: a network analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- A novel framework to quantify dynamic convergence and divergence of overlapping brain states characterizing four psychiatric disorders.Network neuroscience (Cambridge, Mass.) · 2026Article
- The association between gut microbiota and functional connectivity in cognitive impairment of first-episode major depressive disorder.Translational psychiatry · 2025Article
- Classify the fNIRS signals of first-episode drug-naive MDD patients with or without suicidal ideation using machine learning.BMC psychiatry · 2025Article
- Altered triple network model connectivity is associated with cognitive function and depressive symptoms in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
- Decreases in frequency-dependent intrinsic activity of the default mode network are associated with depression and cognition in patients with postacute sequelae of SARS-CoV-2 infection.Brain structure & function · 2025Article
- Alterations of Sensory-related Functional Brain Network Connectivity inPhenomics (Cham, Switzerland) · 2024Article
- The cognitive triad network - oscillation - behaviour links individual differences in EEG theta frequency with task performance and effective connectivity.Scientific reports · 2024Article
- Assessing remission in major depressive disorder using a functional-structural data fusion pipeline: A CAN-BIND-1 study.IBRO neuroscience reports · 2024Article
- Common and divergent neuroimaging features in major depression, posttraumatic stress disorder, and their comorbidity.Psychoradiology · 2024Review
- Does Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder?Neuropsychiatric disease and treatment · 2024Article
- Dynamic network characteristics of adolescents with major depressive disorder: Attention network mediates the association between anhedonia and attentional deficit.Human brain mapping · 2023Article
- Article
- The Ponto-Geniculo-Occipital (PGO) Waves in Dreaming: An Overview.Brain sciences · 2023Review
- Alexithymia characteristics are associated with salience network activity in healthy participants: an arterial spin labeling study.Journal of physiological anthropology · 2023Article
- Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder.BMC psychiatry · 2023Article
- Posterior cingulate cortex targeted real-time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default-mode network in PTSD.Brain and behavior · 2023Article
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5 authors.
Funding
Abstract
backgroundMajor depressive disorder (MDD) is one of the most prevalent and debilitating psychiatric disorders. Cognitive complaints are commonly reported in MDD and cognitive impairment is a criterion item for MDD diagnosis. As cognitive processes are increasingly understood as the consequences of distributed interactions between brain regions, a network-based approach may provide novel information about the neurobiological basis of cognitive deficits in MDD.
methods51 Depressed (MDD, n = 23) and non-depressed (control, n = 28) adult participants completed neuropsychological testing and resting-state fMRI (rsfMRI). Cognitive domain scores (processing speed, working memory, episodic memory, and executive function) were calculated. Anatomical regions of interests were entered as seeds for functional connectivity analyses in: default mode (DMN), salience, and executive control (ECN) networks. Partial correlations controlling for age and sex were conducted for cognitive domain scores and functional connectivity in clusters with significant differences between groups.
resultsSignificant rsfMRI differences between groups were identified in multiple clusters in the DMN and ECN. Greater positive connectivity within the ECN and between ECN and DMN regions was associated with poorer episodic memory performance in the Non-Depressed group but better performance in the MDD group. Greater connectivity within the DMN was associated with better episodic and working memory performance in the Non-Depressed group but worse performance in the MDD group.
conclusionsThese results provide evidence that cognitive performance in MDD may be associated with aberrant functional connectivity in cognitive networks and suggest patterns of alternate brain function that may support cognitive processes in MDD.
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