ArticleThe American journal of pathology2019
Blocking NF-κB Activation in Ly6c
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Article in The American journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- [Multicenter prospective study on the diagnostic value of syndecan-1 for necrotizing enterocolitis in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- All roads lead to NF-κB: the NF-κB pathway as a major target for intestinal inflammatory disorders.Frontiers in immunology · 2026Review
- Necrotizing Enterocolitis: A Comprehensive Review on Toll-like Receptor 4-Mediated Pathophysiology, Clinical, and Therapeutic Insights.Biomedicines · 2025Review
- REGγ-mediated Barrier Disruption and NF-κB Activation Aggravates Intestinal Inflammation in Necrotizing Enterocolitis.Inflammation · 2025Article
- Diagnostic and Prognostic Value of Hematological Parameters in Necrotizing Enterocolitis: A Systematic Review.Journal of clinical medicine · 2025Review
- Purine metabolism in bone marrow microenvironment inhibits hematopoietic stem cell differentiation under microgravity.Stem cell research & therapy · 2025Article
- Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium.Cell host & microbe · 2024Article
- Immunological aspects of necrotizing enterocolitis models: a review.Frontiers in immunology · 2024Review
- New insights into intestinal macrophages in necrotizing enterocolitis: the multi-functional role and promising therapeutic application.Frontiers in immunology · 2023Review
- Feeding mode influences dynamic gut microbiota signatures and affects susceptibility to anti-CD3 mAb-induced intestinal injury in neonatal mice.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Increased expression of OLFM4 and lysozyme during necrotizing enterocolitis in neonates: an observational research study.BMC pediatrics · 2022Observational
- Necrotizing enterocolitis: Bench to bedside approaches and advancing our understanding of disease pathogenesis.Frontiers in pediatrics · 2022Review
- Colonization of fecal microbiota from patients with neonatal necrotizing enterocolitis exacerbates intestinal injury in germfree mice subjected to necrotizing enterocolitis-induction protocol via alterations in butyrate and regulatory T cells.Journal of translational medicine · 2021Article
- Urine-derived extracellular vesicle miRNAs as possible biomarkers for and mediators of necrotizing enterocolitis: A proof of concept study.Journal of pediatric surgery · 2021Article
- CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants.The Journal of experimental medicine · 2021Article
- Role of macrophages in fetal development and perinatal disorders.Pediatric research · 2021Review
- Necrotizing Enterocolitis: LPS/TLR4-Induced Crosstalk Between Canonical TGF-β/Wnt/β-Catenin Pathways and PPARγ.Frontiers in pediatrics · 2021Review
- Cell death of intestinal epithelial cells in intestinal diseases.Sheng li xue bao : [Acta physiologica Sinica] · 2020Review
- Transcriptional profiling of lung macrophages identifies a predictive signature for inflammatory lung disease in preterm infants.Communications biology · 2020Article
- Iron Absorption in Celiac Disease and Nutraceutical Effect of 7-Hydroxymatairesinol. Mini-Review.Molecules (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Elizabeth ManagliaCenter for Intestinal and Liver Inflammation Research, Stanley Manne Children's Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Division of Neonatology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Stanley Manne Children's Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Shirley X L LiuCenter for Intestinal and Liver Inflammation Research, Stanley Manne Children's Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Division of Neonatology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Stanley Manne Children's Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Xiaocai YanCenter for Intestinal and Liver Inflammation Research, Stanley Manne Children's Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Division of Neonatology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Stanley Manne Children's Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Xiao-Di TanCenter for Intestinal and Liver Inflammation Research, Stanley Manne Children's Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Division of Gastroenterology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Stanley Manne Children's Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Department of Pathology, Ann & Robert H. Lurie Children's Hospital of Chicago, Stanley Manne Children's Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Pauline M ChouDepartment of Pathology, Ann & Robert H. Lurie Children's Hospital of Chicago, Stanley Manne Children's Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Terrence A BarrettDivision of Gastroenterology, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky.
Isabelle G De PlaenCenter for Intestinal and Liver Inflammation Research, Stanley Manne Children's Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Division of Neonatology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Stanley Manne Children's Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Electronic address: isabelledp@northwestern.edu.
Northwestern University · USLurie Children's Hospital · USUniversity of Kentucky · US
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MThe Role of Crypt Fissioning in IBD Ulcer HealingR01DK095662 · NIDDK · UNIVERSITY OF KENTUCKY · PI BARRETT, TERRENCE A. · 2012 to 2024
$3.9MSurgical studies of gut epithelial apoptosis-initiated critical illnessR01GM117628 · NIGMS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI TAN, XIAO-DI · 2016 to 2019
$1.9MCell-specific role of NF-KB in necrotizing enterocolitisR01HD060876 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI DE PLAEN, ISABELLE G · 2010 to 2014
$1.5MLymphoepithelial interactions in IBDR01AI061701 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BARRETT, TERRENCE A. · 2005 to 2009
$1.5MMechanisms underlying disruption of intestinal epithelial barrier in critical illnessR01GM122406 · NIGMS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI TAN, XIAO-DI · 2017 to 2018
$594kThe role of Axin2+ stem cells in ulcer healing during colitis.I01CX001353 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI Terrence A. Barrett · 2017 to 2026
–CSRD VA I01 CX001353NCI NIH HHS P30 CA060553NIAID NIH HHS R01 AI061701NICHD NIH HHS R01 HD060876NIDDK NIH HHS R01 DK095662NIGMS NIH HHS R01 GM117628NIGMS NIH HHS R01 GM122406
Abstract
Necrotizing enterocolitis (NEC) is a devastating disease affecting premature infants with intestinal inflammation and necrosis. The neonatal intestinal inflammatory response is rich in macrophages, and blood monocyte count is low in human NEC. We previously found that NF-κB mediates the intestinal injury in experimental NEC. However, the role of NF-κB in myeloid cells during NEC remains unclear. Herein, inhibitor of kappaB kinase β (IKKβ), a critical kinase mediating NF-κB activation, was deleted in lysozyme M (Lysm)-expressing cells, which were found to be Cd11b
Indexed as
AnimalsAntigens, LyEnterocolitis, NecrotizingEpithelial CellsGene DeletionI-kappa B KinaseL-SelectinMacrophagesMiceMice, TransgenicMonocytesNF-kappa BUp-RegulationAntigens, LyI-kappa B KinaseIkbkb protein, mouseL-SelectinLy-6C antigen, mouseNF-kappa B
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.