Evidence map›Paper›PMID 30593566›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric K

Sönke Cordeiro, Rocio K Finol-Urdaneta, David Köpfer, Anna Markushina, Jie Song, Robert J French, Wojciech Kopec, Bert L de Groot, Mario J Giacobassi, Lee S Leavitt and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. In Silico Conotoxin Studies: Progress and Prospects.Molecules (Basel, Switzerland) · 2024
    Review
  10. Review
  11. Article
  12. Article
  13. Voltage-Gated KMarine drugs · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Modeling the kinetics of heteromeric potassium channels.Frontiers in cellular neuroscience · 2022
    Article
  19. Peptide Toxins Targeting KV Channels.Handbook of experimental pharmacology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Sönke CordeiroInstitute of Physiology, Christian-Albrechts-University Kiel, 24118 Kiel, Germany.
Rocio K Finol-UrdanetaIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.ORCID 0000-0003-2157-4532
David KöpferMax-Planck-Institute for Biophysical Chemistry, Computational Biomolecular Dynamics Group, 37077 Göttingen, Germany.
Anna MarkushinaInstitute of Physiology, Christian-Albrechts-University Kiel, 24118 Kiel, Germany.
Jie SongInstitute of Physiology, Christian-Albrechts-University Kiel, 24118 Kiel, Germany.
Robert J FrenchDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.ORCID 0000-0001-8174-026X
Wojciech KopecMax-Planck-Institute for Biophysical Chemistry, Computational Biomolecular Dynamics Group, 37077 Göttingen, Germany.
Bert L de GrootMax-Planck-Institute for Biophysical Chemistry, Computational Biomolecular Dynamics Group, 37077 Göttingen, Germany.
Mario J GiacobassiDepartment of Biology, University of Utah, Salt Lake City, UT 841120.
Lee S LeavittDepartment of Biology, University of Utah, Salt Lake City, UT 841120.
Shrinivasan RaghuramanDepartment of Biology, University of Utah, Salt Lake City, UT 841120.
Russell W TeichertDepartment of Biology, University of Utah, Salt Lake City, UT 841120.
Baldomero M OliveraDepartment of Biology, University of Utah, Salt Lake City, UT 841120 olivera@biology.utah.edu h.terlau@physiologie.uni-kiel.de.ORCID 0000-0003-4556-1410
Heinrich TerlauInstitute of Physiology, Christian-Albrechts-University Kiel, 24118 Kiel, Germany; olivera@biology.utah.edu h.terlau@physiologie.uni-kiel.de.
University of Utah · USChristian-Albrechts-Universität zu Kiel · DEMax Planck Institute for Biophysical Chemistry · DEUniversity of Calgary · CA

Funding

Venoms, Biological Resources, Molecular BiologyP01GM048677 · NIGMS · UNIVERSITY OF UTAH · PI BANDYOPADHYAY, PRADIP K · 1993 to 2018
$32.2M
Canadian Institutes of Health Research MOP-10053NIGMS NIH HHS P01 GM048677
6 · The paper itself

Abstract

The vast complexity of native heteromeric K

Indexed as

ConotoxinsGanglia, SpinalMembrane PotentialsMolecular Dynamics SimulationNeuronsShaker Superfamily of Potassium ChannelsHEK293 CellsHumansIon TransportProtein BindingConotoxinsShaker Superfamily of Potassium Channelsconotoxin kappaM-RIIIJheteromeric Kv-channelsKv1.2

Identifiers

PMID30593566
PMCPMC6338859
OpenAlexW2908303625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.