Evidence map›Paper›PMID 30593560›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Phosphatase PP2A is essential for T

Qin Xu, Xuexiao Jin, Mingzhu Zheng, Deepak Rohila, Guotong Fu, Zhuoyu Wen, Jun Lou, Songquan Wu, Richard Sloan, Lie Wang and 3 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. A genetic variant inScience advances · 2025
    Article
  4. Protein phosphatases in systemic autoimmunity.Immunometabolism (Cobham, Surrey) · 2025
    Review
  5. Protein Phosphatase 2A Promotes CD8Research (Washington, D.C.) · 2025
    Article
  6. Article
  7. Article
  8. The role of IL-22 in cancer.Medical oncology (Northwood, London, England) · 2024
    Review
  9. Article
  10. PP2A catalytic subunit alpha is critically required for CD8bioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Protein Phosphatase 2A: Role in T Cells and Diseases.Journal of immunology research · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Qin XuInstitute of Immunology, and Department of Dermatology and Rheumatology in Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, P. R. China.
Xuexiao JinInstitute of Immunology, and Department of Dermatology and Rheumatology in Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, P. R. China.
Mingzhu ZhengInstitute of Immunology, and Department of Dermatology and Rheumatology in Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, P. R. China.
Deepak RohilaInstitute of Immunology, and Department of Dermatology and Rheumatology in Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, P. R. China.
Guotong FuInstitute of Immunology, and Department of Dermatology and Rheumatology in Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, P. R. China.
Zhuoyu WenInstitute of Immunology, and Department of Dermatology and Rheumatology in Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, P. R. China.
Jun LouInstitute of Immunology, and Department of Dermatology and Rheumatology in Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, P. R. China.
Songquan WuSchool of Medicine, Lishui University, Lishui 323000, Zhejiang Province, P. R. China.
Richard SloanZhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, 310058 Hangzhou, P. R. China.ORCID 0000-0002-8973-1971
Lie WangInstitute of Immunology, and Department of Dermatology and Rheumatology in Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, P. R. China.
Hu HuDepartment of Pathology and Pathophysiology, Zhejiang University School of Medicine, 310058 Hangzhou, P. R. China.
Xiang GaoKey Laboratory of Model Animals for Disease Study of the Ministry of Education, Model Animal Research Center, Nanjing University, 210061 Nanjing, P. R. China; gaoxiang@nju.edu.cn lu_linrong@zju.edu.cn.
Linrong LuInstitute of Immunology, and Department of Dermatology and Rheumatology in Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, P. R. China; gaoxiang@nju.edu.cn lu_linrong@zju.edu.cn.
Sir Run Run Shaw Hospital · CNLishui University · CNModel Animal Research Center · CNZhejiang University · CNZhejiang University-University of Edinburgh Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphatase PP2A expression levels are positively correlated to the clinical severity of systemic lupus erythematosus (SLE) and IL17A cytokine overproduction, indicating a potential role of PP2A in controlling T

Indexed as

Cell DifferentiationEncephalomyelitis, Autoimmune, ExperimentalProtein Phosphatase 2AnimalsInterleukin-17MiceMice, KnockoutNuclear Receptor Subfamily 1, Group F, Member 3PhosphorylationSmad2 ProteinTh17 CellsTranscription, GeneticIl17a protein, mouseInterleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3Protein Phosphatase 2Smad2 ProteinSmad2 protein, mouseEAEPP2ASMAD2/SMAD3TGFβTH17

Identifiers

PMID30593560
PMCPMC6338861
OpenAlexW2908183742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.