Evidence map›Paper›PMID 30593536›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.

Melissa A Gawron, Mark Duval, Claudia Carbone, Smita Jaiswal, Aaron Wallace, Joseph C Martin, Ann Dauphin, Michael A Brehm, Dale L Greiner, Leonard D Shultz and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Humanized mouse models for immuno-oncology research.Nature reviews. Clinical oncology · 2023
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Melissa A GawronMassBiologics of the University of Massachusetts Medical School, Boston, MA 02126.
Mark DuvalMassBiologics of the University of Massachusetts Medical School, Boston, MA 02126.
Claudia CarboneProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655; and.ORCID 0000-0002-2420-8629
Smita JaiswalProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655; and.
Aaron WallaceMassBiologics of the University of Massachusetts Medical School, Boston, MA 02126.ORCID 0000-0003-0876-661X
Joseph C MartinMassBiologics of the University of Massachusetts Medical School, Boston, MA 02126.
Ann DauphinProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655; and.
Michael A BrehmProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655; and.ORCID 0000-0001-6813-3262
Dale L GreinerProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655; and.
Leonard D ShultzThe Jackson Laboratory, Bar Harbor, ME 04609.
Jeremy LubanProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655; and.ORCID 0000-0001-5650-4054
Lisa A CavaciniMassBiologics of the University of Massachusetts Medical School, Boston, MA 02126; lisa.cavacini@umassmed.edu.ORCID 0000-0003-1417-8339
University of Massachusetts Chan Medical School · USJackson Laboratory · US

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Mark D ADAMS · 1985 to 2026
$61.9M
Novel humanized mouse model developed from cord blood CD34 positive HSC and autologous iPS cell derived thymusR01AI132963 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BREHM, MICHAEL ALLEN, MAEHR, RENE · 2017 to 2021
$4.4M
Live imaging of SARS-CoV-2 infection in novel humanized miceR24OD026440 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BREHM, MICHAEL ALLEN, EMERSON, CHARLES P. · 2019 to 2022
$4.2M
Human Genes that Influence HIV-1 Replication, Pathogenesis, and Immunity in IVDUsDP1DA034990 · NIDA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUBAN, JEREMY · 2012 to 2016
$4.1M
Humanized Mouse Avatars for T1DUC4DK104218 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BREHM, MICHAEL ALLEN, DALEY, GEORGE Q · 2014 to 2014
$4.1M
Development and Validation of Novel NSG Mouse Models for Human Stem Cell TherapyR24OD018259 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BREHM, MICHAEL ALLEN, GREINER, DALE LESLIE · 2014 to 2017
$3.0M
Boosting cell-intrinsic innate immune recognition of HIV-1 by dendritic cellsR01AI111809 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUBAN, JEREMY · 2014 to 2017
$2.4M
Mechanism of Potent Neutralization of HIV by IgA CD4i AntibodyR01AI106478 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CAVACINI, LISA A · 2013 to 2016
$1.6M
Combinatorial Beta Cell-Specific Cytokine Therapy to Reverse Type I DiabetesR01DK103546 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TISCH, ROLAND M · 2015 to 2018
$1.5M
NCI NIH HHS P30 CA034196NIAID NIH HHS R01 AI106478NIAID NIH HHS R01 AI111809NIAID NIH HHS R01 AI132963NIDA NIH HHS DP1 DA034990NIDDK NIH HHS UC4 DK104218NIH HHS R24 OD018259NIH HHS R24 OD026440
6 · The paper itself

Abstract

Broadly neutralizing, anti-HIV-1 gp120 mAbs have been isolated from infected individuals, and there is considerable interest in developing these reagents for Ab-based immunoprophylaxis and treatment. As a means to identify potentially new anti-HIV Abs, we exploited humanized NOD-

Indexed as

AnimalsAnimals, Genetically ModifiedAntibodies, Monoclonal, HumanizedAntibodies, NeutralizingHIV-1HIV AntibodiesHIV Envelope Protein gp120HIV InfectionsHumansMiceMice, Inbred NODMice, SCIDNeutralization TestsAntibodies, Monoclonal, HumanizedAntibodies, NeutralizingHIV AntibodiesHIV Envelope Protein gp120

Identifiers

PMID30593536
PMCPMC6344273
OpenAlexW2906864007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.