Evidence map›Paper›PMID 30593509›Full record

ArticleThe Journal of biological chemistry2019

The tuberculosis necrotizing toxin is an NAD

Uday Tak, Jiri Vlach, Acely Garza-Garcia, Doreen William, Olga Danilchanka, Luiz Pedro Sório de Carvalho, Jamil S Saad, Michael Niederweis

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Protein Architecture and Composition in Mycobacterium tuberculosis.Advances in experimental medicine and biology · 2026
    Review
  3. Protein-Mediated Virulence in Mycobacterium tuberculosis.Advances in experimental medicine and biology · 2026
    Review
  4. Review
  5. NADNature communications · 2023
    Article
  6. Article
  7. Article
  8. Apprehending the NADViruses · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Pathogen induced subversion of NADCell death discovery · 2021
    Article
  17. Bioinformatic Analysis of theFrontiers in microbiology · 2021
    Article
  18. AggregatedFrontiers in microbiology · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Uday TakFrom the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35205 and.
Jiri VlachFrom the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35205 and.
Acely Garza-Garciathe Francis Crick Institute, London NW1 1AT, United Kingdom.ORCID 0000-0003-0307-0138
Doreen WilliamFrom the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35205 and.
Olga DanilchankaFrom the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35205 and.
Luiz Pedro Sório de Carvalhothe Francis Crick Institute, London NW1 1AT, United Kingdom.
Jamil S SaadFrom the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35205 and.ORCID 0000-0001-9503-6484
Michael NiederweisFrom the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35205 and mnieder@uab.edu.ORCID 0000-0003-4068-8092
University of Alabama at Birmingham · USThe Francis Crick Institute · GB

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
The necrosis-inducing toxin of Mycobacterium tuberculosisR01AI121354 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NIEDERWEIS, MICHAEL · 2016 to 2020
$2.5M
Cancer Research UK FC001060Medical Research Council FC001060NCI NIH HHS P30 CA013148NIAID NIH HHS R01 AI121354Wellcome Trust FC001060
6 · The paper itself

Abstract

Upon host infection,

Indexed as

Amino Acid SequenceBacterial ToxinsHydrolysisIntracellular SpaceModels, MolecularMycobacterium tuberculosisNADNAD+ NucleosidaseNADPProtein ConformationProtein DomainsBacterial ToxinsNADNAD+ NucleosidaseNADPbacterial toxinenzyme kineticsenzyme mechanismhost-pathogen interactiontuberculosis

Identifiers

PMID30593509
PMCPMC6398120
OpenAlexW2907845265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.