Evidence map›Paper›PMID 30593501›Full record

ArticleThe Journal of biological chemistry2019

Kinetic studies reveal a key role of a redox-active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites.

Bruno Manta, Matías N Möller, Mariana Bonilla, Matías Deambrosi, Karin Grunberg, Massimo Bellanda, Marcelo A Comini, Gerardo Ferrer-Sueta

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Improving pJournal of chemical theory and computation · 2025
    Article
  2. Article
  3. Evaluation of the Anti-Biomedicines · 2022
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Bruno MantaFrom the Grupo Biología Redox de Tripanosomas, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.
Matías N Möllerthe Laboratorio de Fisicoquímica Biológica and.
Mariana BonillaFrom the Grupo Biología Redox de Tripanosomas, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.
Matías DeambrosiFrom the Grupo Biología Redox de Tripanosomas, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.
Karin GrunbergFrom the Grupo Biología Redox de Tripanosomas, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.
Massimo Bellandathe Dipartimento di Scienze Chimiche, Università degli Studi di Padova, Padova 35131, Italy.ORCID 0000-0002-8187-0264
Marcelo A CominiFrom the Grupo Biología Redox de Tripanosomas, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.ORCID 0000-0001-5000-1333
Gerardo Ferrer-Suetathe Laboratorio de Fisicoquímica Biológica and gferrer@fcien.edu.uy.ORCID 0000-0002-8663-8480
Universidad de la República de Uruguay · UYInstitut Pasteur de Montevideo · UYUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trypanosomes are flagellated protozoan parasites (kinetoplastids) that have a unique redox metabolism based on the small dithiol trypanothione (T(SH)

Indexed as

Biological EvolutionAnimalsCatalytic DomainGlutaredoxinsHumansKineticsOxidation-ReductionSulfhydryl CompoundsTrypanosomaGlutaredoxinsSulfhydryl Compoundsdisulfideenzyme catalysisfluorescenceglutathionylationoxidation-reduction (redox)thioltrypanosometrypanothione

Identifiers

PMID30593501
PMCPMC6398122
OpenAlexW2907109441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.