Evidence map›Paper›PMID 30593500›Full record

ArticleThe Journal of biological chemistry2019

Function of a strand-separation pin element in the PriA DNA replication restart helicase.

Tricia A Windgassen, Maxime Leroux, Steven J Sandler, James L Keck

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Characterization of the Chimeric PriB-SSBc Protein.International journal of molecular sciences · 2021
    Article
  8. Article
  9. Dynamics of the PriA Helicase at Stalled DNA Replication Forks.The journal of physical chemistry. B · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tricia A WindgassenFrom the Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706 and.
Maxime Lerouxthe Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01003.
Steven J Sandlerthe Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01003.
James L KeckFrom the Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706 and jlkeck@wisc.edu.ORCID 0000-0002-5961-0220
University of Massachusetts Amherst · USUniversity of Wisconsin–Madison · US

Funding

Structure and Function of the Bacterial PrimosomeR01GM098885 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI James L Keck · 2012 to 2026
$4.0M
NIGMS NIH HHS R01 GM098885
6 · The paper itself

Abstract

DNA helicases are motor proteins that couple the chemical energy of nucleoside triphosphate hydrolysis to the mechanical functions required for DNA unwinding. Studies of several helicases have identified strand-separating "pin" structures that are positioned to intercept incoming dsDNA and promote strand separation during helicase translocation. However, pin structures vary among helicases and it remains unclear whether they confer a conserved unwinding mechanism. Here, we tested the biochemical and cellular roles of a putative pin element within the

Indexed as

DNA ReplicationAmino Acid SequenceCrystallography, X-RayDNADNA, BacterialDNA-Binding ProteinsDNA HelicasesDNA, Single-StrandedEscherichia coliEscherichia coli ProteinsNucleic Acid ConformationProtein ConformationDNADNA, BacterialDNA-Binding ProteinsDNA HelicasesDNA, Single-StrandedEscherichia coli ProteinspriA protein, E coliPriB protein, E coliDNA damage responseDNA helicaseDNA-protein interactionDNA repairDNA replicationDNA replication restartDNA strand-separation mechanismsPriAprimosome assemblyprotein complexprotein cross-linkingstrand-separation pin

Identifiers

PMID30593500
PMCPMC6393597
OpenAlexW2907089385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.