Evidence map›Paper›PMID 30593499›Full record

ArticleThe Journal of biological chemistry2019

Exploiting the vulnerable active site of a copper-only superoxide dismutase to disrupt fungal pathogenesis.

Natalie G Robinett, Edward M Culbertson, Ryan L Peterson, Hiram Sanchez, David R Andes, Jeniel E Nett, Valeria C Culotta

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Molecular medicine reports · 2026
    Article
  2. Article
  3. Article
  4. From hemocuprein to CSRP: the many faces of Cu/Zn superoxide dismutase.Metallomics : integrated biometal science · 2026
    Review
  5. A roadmap to chemically reactive species: how diverse oxidants affectMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Intestinal bacteria-a powerful weapon for fungal infections treatment.Frontiers in cellular and infection microbiology · 2023
    Review
  12. Biochemical Analysis ofACS infectious diseases · 2022
    Article
  13. Review
  14. Review
  15. Ceruloplasmin as a source of Cu for a fungal pathogen.Journal of inorganic biochemistry · 2021
    Article
  16. Interactions between invasive fungi and symbiotic bacteria.World journal of microbiology & biotechnology · 2020
    Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Natalie G RobinettFrom the Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205 and.
Edward M CulbertsonFrom the Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205 and.
Ryan L PetersonFrom the Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205 and.
Hiram Sanchezthe Departments of Medicine and Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53726.
David R Andesthe Departments of Medicine and Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53726.
Jeniel E Nettthe Departments of Medicine and Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53726.
Valeria C CulottaFrom the Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205 and vculott1@jhu.edu.
Johns Hopkins University · USUniversity of Wisconsin–Madison · US

Funding

TRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1M
Vesicle-mediated drug resistance of Candida albicans biofilmR01AI073289 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R, MITCHELL, AARON P · 2008 to 2025
$7.9M
GENETIC DETERMINANTS OF OXYGEN TOXICITYR01GM050016 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CULOTTA, VALERIA C · 1993 to 2018
$3.0M
Copper as a nutrient for Candida albicans at the host-pathogen interfaceR01AI119949 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CULOTTA, VALERIA C · 2015 to 2019
$2.3M
Mechanisms of Candida Biofilm Immune EvasionK08AI108727 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI NETT, JENIEL E · 2014 to 2018
$960k
Kidney Cu Homeostasis and Ceruloplasmin during Infection and InflammationF31DK111114 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CULBERTSON, EDWARD MCLOUTH · 2016 to 2019
$177k
Candida albicans SOD5: a novel copper-only superoxide dismutaseF32GM112320 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI PETERSON, RYAN LOREN · 2014 to 2015
$107k
Doris Duke Charitable Foundation 2017074NCI NIH HHS T32 CA009110NIAID NIH HHS K08 AI108727NIAID NIH HHS R01 AI073289NIAID NIH HHS R01 AI119949NIDDK NIH HHS F31 DK111114NIGMS NIH HHS F32 GM112320NIGMS NIH HHS R01 GM050016
6 · The paper itself

Abstract

Copper-only superoxide dismutases (SODs) represent a new class of SOD enzymes that are exclusively extracellular and unique to fungi and oomycetes. These SODs are essential for virulence of fungal pathogens in pulmonary and disseminated infections, and we show here an additional role for copper-only SODs in promoting survival of fungal biofilms. The opportunistic fungal pathogen

Indexed as

AnimalsBiofilmsCandida albicansCandidemiaCatalytic DomainCatheter-Related InfectionsCathetersCopperEnzyme InhibitorsFungal ProteinsProtein ConformationRatsSuperoxide DismutaseZincCopperEnzyme InhibitorsFungal ProteinsSuperoxide DismutaseZincCandidacopperCu-only SODfungimetalloenzymemycocidesuperoxide dismutase (SOD)superoxide ionvirulenceyeast

Identifiers

PMID30593499
PMCPMC6393590
OpenAlexW2908112180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.