Evidence map›Paper›PMID 30593376›Full record

ArticleVeterinary microbiology2019

Pre-exposure with influenza A virus A/WSN/1933(H1N1) resulted in viral shedding reduction from pigs challenged with either swine H1N1 or H3N2 virus.

Zhao Wang, Jieshi Yu, Milton Thomas, Chithra C Sreenivasan, Ben M Hause, Dan Wang, David H Francis, Radhey S Kaushik, Feng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Zhao WangDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD, 57007, USA; China Institute of Veterinary Drug Control, 8 Zhongguancun S St, Beijing, China.
Jieshi YuDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD, 57007, USA.
Milton ThomasDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD, 57007, USA.
Chithra C SreenivasanDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD, 57007, USA.
Ben M HauseCambridge Technologies, Oxford Street Worthington, MN, 56187, USA.
Dan WangDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD, 57007, USA; BioSNTR, Brookings, SD, 57007, USA.
David H FrancisDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD, 57007, USA.
Radhey S KaushikDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD, 57007, USA. Electronic address: radhey.kaushik@sdstate.edu.
Feng LiDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD, 57007, USA; BioSNTR, Brookings, SD, 57007, USA. Electronic address: feng.li@sdstate.edu.
South Dakota State University · USBrookings Institution · US

Funding

Stimulation of broadly neutralizing antibodies against influenza in a pig modelR15AI089690 · NIAID · SOUTH DAKOTA STATE UNIVERSITY · PI FRANCIS, DAVID HULET, KAUSHIK, RADHEY SHYAM · 2011 to 2011
$424k
NIAID NIH HHS R15 AI089690
6 · The paper itself

Abstract

There is an urgent need to develop a broad-spectrum vaccine that can effectively prevent or eliminate the spread of co-circulating swine influenza virus strains in multiple lineages or subtypes. We describe here that pre-exposure with a live virus generated via a A/WSN/1933(H1N1) reverse genetics system resulted in a significant reduction of viral shedding from pigs exposed to either a swine H1N1 virus or a swine H3N2 virus. At 3-day post challenge (DPC), approximately 1 log and 1.5 logs reductions of viral shedding were observed in the swine H1N1- and H3N2-challenged vaccinated pigs when compared to unvaccinated animals. A further decline in viral load was observed at 5 DPC where viral shedding was decreased by greater than 3 logs in vaccinated pigs receiving either the H1N1 or H3N2 virus challenge. Although the sera of the vaccinated pigs contained high titers of neutralizing antibodies against the vaccine strain, measured by Hemagglutination Inhibition (HI) assay, only suboptimal HI titers of neutralizing antibody were detected in the post-challenge serum of the vaccinated animals using the challenge swine H1N1 virus. The substantial genetic and antigenic differences between the vaccine virus and the challenge viruses imply that the observed protection may be mediated by mechanisms other than neutralization by IgG, such as non-neutralizing antibody activities, mucosal immunity, or conserved T cell immunity, which warrants further investigation.

Indexed as

Cross ProtectionAnimalsDogsHEK293 CellsHemagglutination Inhibition TestsHumansInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeMadin Darby Canine Kidney CellsMaleOrthomyxoviridae InfectionsPhylogenySwineTestisVaccinationVirus SheddingAntibodyCross-subtype protectionH1 subtypeH3 subtypeSwine influenzaVaccine

Identifiers

PMID30593376
PMCPMC6314213
OpenAlexW2901087267

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.