Evidence map›Paper›PMID 30593282›Full record

ArticleMolecular brain2018

In memoriam: John Lisman - commentaries on CaMKII as a memory molecule.

Mark F Bear, Sam F Cooke, Karl Peter Giese, Bong-Kiun Kaang, Mary B Kennedy, Ji-Il Kim, Richard G M Morris, Pojeong Park

Abstract read
In one paragraph

Article in Molecular brain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mark F BearPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. mbear@mit.edu.
Sam F CookeKing's College London, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF, UK. samuel.cooke@kcl.ac.uk.
Karl Peter GieseKing's College London, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF, UK. karl.giese@kcl.ac.uk.
Bong-Kiun KaangDepartment of Biological Sciences, Seoul National University, Gwanak-gu, Seoul, Republic of Korea. kaang@snu.ac.kr.
Mary B KennedyThe Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA. kennedym@caltech.edu.
Ji-Il KimDepartment of Biological Sciences, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
Richard G M MorrisLaboratory for Cognitive Neuroscience, Centre for Discovery Brain Sciences, Edinburgh Neuroscience, Edinburgh, EH8 9JZ, UK. r.g.m.morris@ed.ac.uk.
Pojeong ParkDepartment of Biological Sciences, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.

Funding

Behavioral Consequences and cellular substrates of plasticity in visual cortexR01EY023037 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BEAR, MARK F · 2013 to 2025
$6.0M
Binding of synGAP to PDZ domains of PSD-95 and its role in Intellectual Disability and Autism Spectrum Disorders caused by synGAP haploinsufficiencyR01MH115456 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KENNEDY, MARY B · 2018 to 2021
$1.7M
CRCNS: Modeling Activation of CaMKII in SpinesR01DA030749 · NIDA · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KENNEDY, MARY B, SEJNOWSKI, TERRENCE J · 2010 to 2013
$1.2M
Medical Research Council MR/N026063/1NEI NIH HHS R01 EY023037NIDA NIH HHS R01 DA030749
6 · The paper itself

Abstract

Shortly before he died in October 2017, John Lisman submitted an invited review to Molecular Brain on 'Criteria for identifying the molecular basis of the engram (CaMKII, PKMζ)'. John had no opportunity to read the referees' comments, and as a mark of the regard in which he was held by the neuroscience community the Editors decided to publish his review as submitted. This obituary takes the form of a series of commentaries on Lisman's review. At the same time we are publishing as a separate article a longer response by Todd Sacktor and André Fenton entitled 'What does LTP tell us about the roles of CaMKII and PKMζ in memory?' which presents the case for a rival memory molecule, PKMζ.

Indexed as

MemoryAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2HippocampusHumansLong-Term PotentiationNeuronal PlasticityProtein Kinase CProtein Kinase C zetaCalcium-Calmodulin-Dependent Protein Kinase Type 2Protein Kinase CProtein Kinase C zeta

Identifiers

PMID30593282
PMCPMC6309094

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.