Evidence map›Paper›PMID 30593270›Full record

ArticleBMC neurology2018

Myasthenia gravis following human papillomavirus vaccination: a case report.

Ji Yeon Chung, Seung Jae Lee, Byoung-Soo Shin, Hyun Goo Kang

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Ocular motility disorders following coronavirus disease-19 vaccination.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Article
  8. COVID-19 Vaccination and Late-Onset Myasthenia Gravis: A New Case Report and Review of the Literature.International journal of environmental research and public health · 2022
    Review
  9. Review
  10. New-onset myasthenia gravis after mRNA SARS-CoV-2 vaccination: a case series.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  11. Article
  12. Observational
  13. Early-Onset Myasthenia Gravis Following COVID-19 Vaccination.Journal of Korean medical science · 2022
    Article
  14. Is Myasthenia Gravis a Real Complication of the COVID-19 Vaccine? A Case Report-Based Systematic Review.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Review
  15. Myasthenia Gravis Presenting after Administration of the mRNA-1273 Vaccine.European journal of case reports in internal medicine · 2022
    Article
  16. Review
  17. Adverse events following pediatric immunization in an Indian city.Clinical and experimental vaccine research · 2021
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Ji Yeon ChungDepartment of Neurology, Chosun University School of Medicine, Gwangju, 61453, Republic of Korea.
Seung Jae LeeInstitute for Molecular Biology and Genetics and Department of Chemistry, Chonbuk National University, Jeonju, 54896, Republic of Korea.
Byoung-Soo ShinDepartment of Neurology, Chonbuk National University School of Medicine, Jeonju, 54896, Republic of Korea.
Hyun Goo KangDepartment of Neurology, Chonbuk National University School of Medicine, Jeonju, 54896, Republic of Korea. hgkang@jbnu.ac.kr.ORCID http://orcid.org/0000-0001-5443-3635
Jeonbuk National University Hospital · KRChosun University · KRJeonbuk National University · KR

Funding

Ministry of Education 2017R1A1A03015876Ministry of Science, ICT and Future Planning 2017R1C1B5017293
6 · The paper itself

Abstract

backgroundMyasthenia gravis (MG), an autoimmune neuromuscular disorder, occurs owing to autoantibodies against acetylcholine receptors. MG symptoms can be triggered by various vaccines. Many studies have evaluated the safety and adverse events of the human papillomavirus (HPV) vaccine. Here, we present a life-threatening case of ocular and bulbar MG symptoms after HPV vaccination and a brief literature review. CASE PRESENTATION: A 23-year-old woman presented with binocular diplopia, ptosis, dysarthria, and dysphagia, which occurred on the 3rd day after the second HPV vaccine administration. She was diagnosed with MG based on history, clinical features, and test results. Her symptoms deteriorated on the 3rd day after admission, and she was transferred to the intensive care unit with mechanical ventilation. On the 7th day after admission, due to discomfort in the right chest, pulmonary embolism was suspected. A tracheostomy was performed on the 14th day of mechanical ventilation. In the 4th week, the tracheostomy tube was removed; all symptoms had completely resolved at discharge. She was followed up for 5 months without recurrence or further treatment.

conclusionHPV vaccination may cause MG owing to unexpected abnormal autoimmune responses. Additional studies are needed to clarify the possible causal relationship between the HPV vaccine and neurological complications and to evaluate the safety of the vaccine.

Indexed as

AutoantibodiesDeglutition DisordersDysarthriaFemaleHumansMyasthenia GravisPapillomavirus VaccinesPulmonary EmbolismReceptors, CholinergicVaccinationYoung AdultAutoantibodiesPapillomavirus VaccinesReceptors, CholinergicAdverse eventHuman papillomavirus vaccineMyasthenia gravisMyasthenia gravis crisisVaccination

Identifiers

PMID30593270
PMCPMC6309058
OpenAlexW2908315896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.