ArticleBirth defects research2019
Maternal residential exposure to specific agricultural pesticide active ingredients and birth defects in a 2003-2005 North Carolina birth cohort.
Article in Birth defects research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Urinary Glyphosate Concentrations among Pregnant Participants in a Randomized, Crossover Trial of Organic and Conventional Diets.Environmental health perspectives · 2023Trial
- Exposure to pesticides in drinking water during pregnancy and risk of congenital malformations: a systematic review protocol.BMJ open · 2026Article
- Determinants of residential pesticide contamination in vineyard regions: a structural equation modeling approach.Journal of exposure science & environmental epidemiology · 2026Article
- Persistent Organic Pollutants and Heart Rate Variability: A Population-Based Cross-Sectional Study in China.Journal of the American Heart Association · 2025Article
- Risk-based mapping of pesticide usage and social vulnerability in the contiguous United States.BMC public health · 2025Article
- Pre and postnatal exposure to glyphosate-based herbicides and potential neurodevelopmental outcomes: a systematic review of animal and epidemiological studies.Toxicological research · 2025Review
- Mapping temporal trends of pesticide use and identifying potential non-occupation population exposure using a geospatial approach.Scientific reports · 2025Article
- Review
- Sociodemographic and dietary determinants of glyphosate exposure in a NYC-based pregnancy cohort.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Lead brownfields and birth defects in North Carolina 2003-2015: A cross-sectional case-control study.Birth defects research · 2024Article
- Maternal pesticide exposure and risk of birth defects: a population-based cross-sectional study in China.Frontiers in public health · 2024Article
- Perinatal health effects of herbicides exposures in the United States: the Heartland Study, a Midwestern birth cohort study.BMC public health · 2023Article
- Glyphosate exposure and preterm birth: A nested case-control pilot study.Reproductive toxicology (Elmsford, N.Y.) · 2023Article
- Exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, Brazil.Frontiers in public health · 2023Article
- Parental smoking and risk of hypospadias: An updated meta-analysis of observational studies.Frontiers in pediatrics · 2023Review
- Characterization of Urinary Pesticide Metabolite Concentrations of Pregnant Women in Suriname.Toxics · 2022Article
- Association of Glyphosate Exposure with Blood DNA Methylation in a Cross-Sectional Study of Postmenopausal Women.Environmental health perspectives · 2022Article
- A cross-sectional study of brownfields and birth defects.Birth defects research · 2022Article
- Association between increasing agricultural use of 2,4-D and population biomarkers of exposure: findings from the National Health and Nutrition Examination Survey, 2001-2014.Environmental health : a global access science source · 2022Article
- The Role of Maternal and Environmental Factors During Pregnancy on the Risk of Hypospadias Occurrence.Global pediatric health · 2022Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundPreviously we observed elevated odds ratios (ORs) for total pesticide exposure and 10 birth defects: three congenital heart defects and structural defects affecting the gastrointestinal, genitourinary and musculoskeletal systems. This analysis examines association of those defects with exposure to seven commonly applied pesticide active ingredients.
methodsCases were live-born singleton infants from the North Carolina Birth Defects Monitoring Program linked to birth records for 2003-2005; noncases served as controls (total n = 304,906). Pesticide active ingredient exposure was assigned using a previously constructed metric based on crops within 500 m of residence, dates of pregnancy, and likely chemical application dates for each pesticide-crop combination. ORs (95% CI) were estimated with logistic regression for categories of exposure compared to unexposed. Models were adjusted for maternal race/ethnicity, age at delivery, education, marital status, and smoking status.
resultsAssociations varied by birth defect and pesticide combinations. For example, hypospadias was positively associated with exposures to 2,4-D (OR
conclusionOur results suggest differing patterns of association for birth defects with residential exposure to seven pesticide active ingredients in North Carolina.
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