Evidence map›Paper›PMID 30591938›Full record

ArticleGenes & diseases2018

Targeted metabolomics of sulfated bile acids in urine for the diagnosis and grading of intrahepatic cholestasis of pregnancy.

Yuchao Li, Xiaoqing Zhang, Jianbo Chen, Chengya Feng, Yifan He, Yong Shao, Min Ding

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  14. A review of analytical platforms for accurate bile acid measurement.Analytical and bioanalytical chemistry · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yuchao LiKey Laboratory of Clinical Laboratory Diagnostics, Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, PR China.
Xiaoqing ZhangKey Laboratory of Clinical Laboratory Diagnostics, Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, PR China.
Jianbo ChenGuangzhou Kingmed Center for Clinical Laboratory, Guangzhou, 510005, PR China.
Chengya FengKey Laboratory of Clinical Laboratory Diagnostics, Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, PR China.
Yifan HeKey Laboratory of Clinical Laboratory Diagnostics, Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, PR China.
Yong ShaoDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, PR China.
Min DingKey Laboratory of Clinical Laboratory Diagnostics, Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, PR China.
Chongqing Medical University · CNChildren's Hospital of Chongqing Medical University · CNKingmed Diagnostics · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is related to cholestatic disorder in pregnancy. Total urinary sulfated bile acids (SBAs) were found increased in ICP. We distinguished the metabolic profiling of urinary SBAs in ICP to find potential biomarkers for the diagnosis and grading of ICP. The targeted metabolomics based on high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used to analyze urinary SBAs profiling in mild and severe ICP cases, as well as healthy controls. 16 kinds of urinary SBAs were determined by HPLC-MS/MS. Sulfated dihydroxy glycine bile acid (di-GBA-S), glycine cholic acid 3-sulfate (GCA-3S), sulfated dihydroxy taurine bile acid (di-TBA-S) and taurine cholic acid 3-sulfate (TCA-3S) increased significantly in ICP group compared with the control group. Seven kinds of SBAs were significantly different (

Indexed as

BiomarkerHPLC-MS/MSIntrahepatic cholestasis of pregnancySulfated bile acidsTargeted metabolomicsUrine

Identifiers

PMID30591938
PMCPMC6304334
OpenAlexW2790286369

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.