Evidence map›Paper›PMID 30591918›Full record

ArticleOpen forum infectious diseases2017

Differentiated Care Pathways for Antiretroviral Therapy Monitoring in Malawi: Expanding Viral Load Testing in Setting of Highly Prevalent Resistance.

Sarah E Rutstein, Kara Compliment, Julie A E Nelson, Deborah Kamwendo, Ronald Mataya, William C Miller, Mina C Hosseinipour

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah E RutsteinDepartment of Health Policy and Management, University of North Carolina at Chapel Hill.
Kara ComplimentUNC Center for AIDS Research, University of North Carolina at Chapel Hill.
Julie A E NelsonUNC Center for AIDS Research, University of North Carolina at Chapel Hill.
Deborah KamwendoUNC Project, Lilongwe, Malawi.
Ronald MatayaSchool of Public Health, Loma Linda University, California.
William C MillerDivision of Infectious Diseases, University of North Carolina at Chapel Hill.
Mina C HosseinipourDivision of Infectious Diseases, University of North Carolina at Chapel Hill.

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008719 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI, DESHMUKH, MOHANISH P · 1999 to 2023
$15.1M
Optimizing HIV Therapy: virological monitoring, adherence & cost-effectivenessF30MH098731 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUTSTEIN, SARAH E. · 2012 to 2016
$201k
NIAID NIH HHS P30 AI050410NIGMS NIH HHS T32 GM008719NIMH NIH HHS F30 MH098731
6 · The paper itself

Abstract

We quantified resistance to first-line antiretroviral therapy among previously unmonitored patients in Malawi with viremia (≥1000 copies/mL). Ninety-five percent (n = 57/61) harbored nucleoside/tide reverse transcriptase inhibitor/non-nucleoside reverse transcriptase inhibitor resistance; resistance was more common comparing >2 (97%) versus ≤2 years (87%) on therapy. Immediate switch for persons retained in care may improve monitoring efficiency and maximize clinical outcomes.

Indexed as

antiretroviral therapyhuman immunodeficiency virus (HIV)resistanceresource-limited settingsviral load monitoring

Identifiers

PMID30591918
PMCPMC6300304

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.