ArticleHigh-throughput2018
Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models.
Article in High-throughput, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05473325 (Preclinical Drug Discovery Informed by Public Health), which is not on this map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preclinical Drug Discovery Informed by Public Health: Initiating a Step-Change in the Development of New Human Models
Who cites it
30 citing papers in PubMed, 83 citations in OpenAlex.
- The molecular ICU: a primer on omics, informatics and the future of precision critical care.Critical care (London, England) · 2026Review
- Detection Limits of Blood Metabolites at Physiological Concentrations Using BenchtopNMR in biomedicine · 2026Article
- Benchtop NMR in Biomedicine: An Updated Literature Overview.Metabolites · 2025Review
- Benchtop NMR urine metabolomics for diagnosing pulmonary tuberculosis.Scientific reports · 2025Article
- Article
- Benchtop Proton NMR Spectroscopy for High-Throughput Lipoprotein Quantification in Human Serum and Plasma.Analytical chemistry · 2025Article
- NMR Based Methods for Metabolites Analysis.Analytical chemistry · 2025Review
- Low-field NMR with multilayer Halbach magnet and NMR selective excitation.Scientific reports · 2023Article
- Article
- Benchtop NMR-Based Metabolomics: First Steps for Biomedical Application.Metabolites · 2023Review
- Application of Benchtop NMR for Metabolomics Study Using Feces of Mice with DSS-Induced Colitis.Metabolites · 2023Article
- Low-Field Benchtop NMR Spectroscopy for Quantification of Aldehydic Lipid Oxidation Products in Culinary Oils during Shallow Frying Episodes.Foods (Basel, Switzerland) · 2023Article
- NMR Metabolomics Methods for Investigating Disease.Analytical chemistry · 2023Review
- Review
- Preliminary demonstration of benchtop NMR metabolic profiling of feline urine: chronic kidney disease as a case study.BMC research notes · 2021Article
- Article
- Article
- The Role of Gut Microbiota and Its Produced Metabolites in Obesity, Dyslipidemia, Adipocyte Dysfunction, and Its Interventions.Metabolites · 2021Review
- Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms.Metabolites · 2021Review
- Chronic Kidney Disease Cohort Studies: A Guide to Metabolome Analyses.Metabolites · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Novel sensing technologies for liquid biopsies offer promising prospects for the early detection of metabolic conditions through omics techniques. Indeed, high-field nuclear magnetic resonance (NMR) facilities are routinely used for metabolomics investigations on a range of biofluids in order to rapidly recognise unusual metabolic patterns in patients suffering from a range of diseases. However, these techniques are restricted by the prohibitively large size and cost of such facilities, suggesting a possible role for smaller, low-field NMR instruments in biofluid analysis. Herein we describe selected biomolecule validation on a low-field benchtop NMR spectrometer (60 MHz), and present an associated protocol for the analysis of biofluids on compact NMR instruments. We successfully detect common markers of diabetic control at low-to-medium concentrations through optimised experiments, including α-glucose (≤2.8 mmol/L) and acetone (25 µmol/L), and additionally in readily accessible biofluids, particularly human urine. We present a combined protocol for the analysis of these biofluids with low-field NMR spectrometers for metabolomics applications, and offer a perspective on the future of this technique appealing to 'point-of-care' applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.