ArticleThe Journal of biological chemistry2019
HIV-1 Tat protein promotes neuronal dysregulation by inhibiting E2F transcription factor 3 (E2F3).
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Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Hepatic and Brain Spatial Gene Expression Changes in Intragastric Alcohol Fed APP/PS1 Alzheimer's Disease Mouse Model.Research square · 2026Article
- Memory Impairments: Type, Causes, and Molecular Players-Memory Dysfunction Across Neurologic Insults.Cells · 2026Review
- HIV Vpr induces demethylation of the SNCA antisense promoter, leading to neurocognitive impairment.Scientific reports · 2026Article
- The OLR1/NF-κB feedback loop exacerbates HIV-1 Tat-induced microglial inflammatory response and neuronal apoptosis.Journal of neurovirology · 2025Article
- Caffeine upregulates SIRT3 expression to ameliorate astrocytes-mediated HIV-1 Tat neurotoxicity via suppression of EGR1 signaling pathway.Journal of neurovirology · 2024Article
- Proteomic snapshot of saliva samples predicts new pathways implicated in SARS-CoV-2 pathogenesis.Clinical proteomics · 2024Article
- Disruption of Mitochondrial-associated ER membranes by HIV-1 tat protein contributes to premature brain aging.CNS neuroscience & therapeutics · 2023Article
- Advancing basic and translational research to deepen understanding of the molecular immune-mediated mechanisms regulating long-term persistence of HIV-1 in microglia in the adult human brain.Journal of leukocyte biology · 2022Review
- Integrated Analysis of the miRNA-mRNA Regulatory Network Involved in HIV-Associated Neurocognitive Disorder.Pathogens (Basel, Switzerland) · 2022Article
- Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders.Frontiers in cellular neuroscience · 2022Article
- HIV-1 Tat induced microglial EVs leads to neuronal synaptodendritic injury: microglia-neuron cross-talk in NeuroHIV.Extracellular vesicles and circulating nucleic acids · 2022Article
- HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein.Frontiers in aging neuroscience · 2022Article
- Multiple Alu Exonization in 3'UTR of a Primate-Specific Isoform of CYP20A1 Creates a Potential miRNA Sponge.Genome biology and evolution · 2021Article
- HIV Tat-Mediated Induction of Monocyte Transmigration Across the Blood-Brain Barrier: Role of Chemokine Receptor CXCR3.Frontiers in cell and developmental biology · 2021Article
- Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine.Frontiers in neurology · 2021Article
- A candidate gene study of intermediate histopathological phenotypes in HIV-associated neurocognitive disorders.Journal of neurovirology · 2020Article
- Region-specific effects of HIV-1 Tat on intrinsic electrophysiological properties of pyramidal neurons in mouse prefrontal cortex and hippocampus.Journal of neurophysiology · 2020Article
- Isoprene-Derived Secondary Organic Aerosol Induces the Expression of MicroRNAs Associated with Inflammatory/Oxidative Stress Response in Lung Cells.Chemical research in toxicology · 2020Article
- Article
- The Role of Brain Derived Neurotrophic Factor in HIV-Associated Neurocognitive Disorder: From the Bench-Top to the Bedside.Neuropsychiatric disease and treatment · 2020Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Maryline SanterreFrom the Molecular Studies of Neurodegenerative Diseases Laboratory, FELS Institute for Cancer Research and Molecular Biology.ORCID 0000-0003-4650-6552
Asen BagashevFrom the Molecular Studies of Neurodegenerative Diseases Laboratory, FELS Institute for Cancer Research and Molecular Biology.
Laura GoreckiFrom the Molecular Studies of Neurodegenerative Diseases Laboratory, FELS Institute for Cancer Research and Molecular Biology.
Kyle Z LysekFrom the Molecular Studies of Neurodegenerative Diseases Laboratory, FELS Institute for Cancer Research and Molecular Biology.
Ying WangFrom the Molecular Studies of Neurodegenerative Diseases Laboratory, FELS Institute for Cancer Research and Molecular Biology.
Jenny ShresthaFrom the Molecular Studies of Neurodegenerative Diseases Laboratory, FELS Institute for Cancer Research and Molecular Biology.
Fabiola Del Carpio-CanoFrom the Molecular Studies of Neurodegenerative Diseases Laboratory, FELS Institute for Cancer Research and Molecular Biology.
Ruma MukerjeeFrom the Molecular Studies of Neurodegenerative Diseases Laboratory, FELS Institute for Cancer Research and Molecular Biology.
Bassel E SawayaFrom the Molecular Studies of Neurodegenerative Diseases Laboratory, FELS Institute for Cancer Research and Molecular Biology, sawaya@temple.edu.
Molecular Oncology (United States) · US
Funding
PGC-1alpha and Reelin: new players in HAND progression.R01AG054411 · NIA · TEMPLE UNIV OF THE COMMONWEALTH · PI SAWAYA, BASSEL E · 2017 to 2021
$2.0MInvolvement of HIV-1 Vpr in neuronal degeneration.R01NS076402 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI SAWAYA, BASSEL E · 2011 to 2015
$1.9MRole of p53 family in neuropathogenesis in AIDSR01NS059327 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI SAWAYA, BASSEL E · 2008 to 2012
$1.9MRole of microRNA in HIV associated neurological disorder (HAND).R01MH093331 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI SAWAYA, BASSEL E · 2011 to 2013
$1.1MNIA NIH HHS R01 AG054411NIMH NIH HHS R01 MH093331NINDS NIH HHS R01 NS059327NINDS NIH HHS R01 NS076402
Abstract
Individuals who are infected with HIV-1 accumulate damage to cells and tissues (
Indexed as
AnimalsBrain-Derived Neurotrophic FactorCell Line, TumorCyclic AMP Response Element-Binding ProteinE2F3 Transcription FactorGene Expression RegulationHumansLong-Term PotentiationMiceMicroRNAsNeuritesNeuronsPromoter Regions, GeneticSynaptophysintat Gene Products, Human Immunodeficiency VirusBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinE2F3 protein, humanE2F3 Transcription FactorMicroRNAsMIRN34 microRNA, humanSynaptophysintat Gene Products, Human Immunodeficiency Virusbrain derived neurotropic factorcognitive disorderCREB promoterE2F3E2F transcription factorhuman immunodeficiency virus (HIV)microRNA (miRNA)miR-34aneurite outgrowthneurodegenerationneurodegenerative disease
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.