Evidence map›Paper›PMID 30591566›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Bioactive cell-like hybrids from dendrimersomes with a human cell membrane and its components.

Srujana S Yadavalli, Qi Xiao, Samuel E Sherman, William D Hasley, Michael L Klein, Mark Goulian, Virgil Percec

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Voltammetric determination of doxycycline in feedstock using modified carbon screen-printed electrode.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Ionic Combisomes: A New Class of Biomimetic Vesicles to Fuse with Life.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  12. Increased efficiency of charge-mediated fusion in polymer/lipid hybrid membranes.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. Article
  14. Nanovesicles displaying functional linear and branched oligomannose self-assembled from sequence-defined Janus glycodendrimers.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  15. Article
  16. Article
  17. Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  18. Encoding biological recognition in a bicomponent cell-membrane mimic.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Srujana S YadavalliDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104-6313.ORCID 0000-0002-4335-1973
Qi XiaoRoy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323.ORCID 0000-0002-6470-0407
Samuel E ShermanRoy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323.
William D HasleyRoy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323.
Michael L KleinInstitute of Computational Molecular Science, Temple University, Philadelphia, PA 19122; mlklein@temple.edu goulian@sas.upenn.edu percec@sas.upenn.edu.
Mark GoulianDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104-6313; mlklein@temple.edu goulian@sas.upenn.edu percec@sas.upenn.edu.
Virgil PercecRoy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323; mlklein@temple.edu goulian@sas.upenn.edu percec@sas.upenn.edu.
University of Pennsylvania · USRutgers, The State University of New Jersey · USTemple University · US

Funding

Regulation of Bacterial Two-Component Signaling by Small Membrane ProteinsR01GM080279 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D · 2007 to 2020
$3.7M
NIGMS NIH HHS R01 GM080279
6 · The paper itself

Abstract

Cell-like hybrids from natural and synthetic amphiphiles provide a platform to engineer functions of synthetic cells and protocells. Cell membranes and vesicles prepared from human cell membranes are relatively unstable in vitro and therefore are difficult to study. The thicknesses of biological membranes and vesicles self-assembled from amphiphilic Janus dendrimers, known as dendrimersomes, are comparable. This feature facilitated the coassembly of functional cell-like hybrid vesicles from giant dendrimersomes and bacterial membrane vesicles generated from the very stable bacterial

Indexed as

Artificial CellsCell MembraneCytoplasmic VesiclesDendrimersEscherichia coliEscherichia coli ProteinsGreen Fluorescent ProteinsHEK293 CellsHeLa CellsHumansDendrimersEscherichia coli ProteinsGreen Fluorescent Proteinsbacterial adhesinbacterial membranecoassemblyhybrid vesiclesmammalian cell

Identifiers

PMID30591566
PMCPMC6338876
OpenAlexW2907375530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.