Evidence map›Paper›PMID 30591565›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Two symmetric arginine residues play distinct roles in

Jinping Lei, Gang Sheng, Peter Pak-Hang Cheung, Shenglong Wang, Yu Li, Xin Gao, Yingkai Zhang, Yanli Wang, Xuhui Huang

Open access · bronzeAbstract readVideo-Audio Media
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Jinping LeiDepartment of Chemistry, Center of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration & Reconstruction, The Hong Kong University of Science and Technology, 190, Clear Water Bay, Kowloon, Hong Kong.
Gang ShengKey Laboratory of RNA Biology, Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China.
Peter Pak-Hang CheungDepartment of Chemistry, Center of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration & Reconstruction, The Hong Kong University of Science and Technology, 190, Clear Water Bay, Kowloon, Hong Kong.
Shenglong WangDepartment of Chemistry, New York University, New York, NY 10003.
Yu LiComputational Bioscience Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, 23955-6900 Thuwal, Saudi Arabia.ORCID 0000-0002-3664-6722
Xin GaoComputational Bioscience Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, 23955-6900 Thuwal, Saudi Arabia.
Yingkai ZhangDepartment of Chemistry, New York University, New York, NY 10003; yz22@nyu.edu ylwang@ibp.ac.cn xuhuihuang@ust.hk.
Yanli WangKey Laboratory of RNA Biology, Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China; yz22@nyu.edu ylwang@ibp.ac.cn xuhuihuang@ust.hk.
Xuhui HuangDepartment of Chemistry, Center of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration & Reconstruction, The Hong Kong University of Science and Technology, 190, Clear Water Bay, Kowloon, Hong Kong; yz22@nyu.edu ylwang@ibp.ac.cn xuhuihuang@ust.hk.ORCID 0000-0002-7119-9358
Hong Kong University of Science and Technology · HKChinese Academy of Sciences · CNKing Abdullah University of Science and Technology · SANew York University · USNew York University Shanghai · CN

Funding

Computational modulator design and machine learning to target protein-protein interactionsR35GM127040 · NIGMS · NEW YORK UNIVERSITY · PI Yingkai Zhang · 2018 to 2026
$4.6M
NIGMS NIH HHS R35 GM127040
6 · The paper itself

Abstract

Bacterium

Indexed as

Argonaute ProteinsCatalytic DomainDNAMolecular Dynamics SimulationThermus thermophilusArgonaute ProteinsDNAbacterial ArgonauteDNA cleavageQM/MM simulations

Identifiers

PMID30591565
PMCPMC6338865
OpenAlexW2907072798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.