Evidence map›Paper›PMID 30591524›Full record

ArticleEMBO reports2019

AGO2 promotes telomerase activity and interaction between the telomerase components TERT and TERC.

Ilaria Laudadio, Francesca Orso, Gianluca Azzalin, Carlo Calabrò, Francesco Berardinelli, Elisa Coluzzi, Silvia Gioiosa, Daniela Taverna, Antonella Sgura, Claudia Carissimi and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
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  4. CRISPR-based mFrontiers in cell and developmental biology · 2023
    Review
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  6. Article
  7. Article
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  9. Article
  10. Article
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  13. Article
  14. Article
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  17. Article
  18. How RNAi machinery enters the world of telomerase.Cell cycle (Georgetown, Tex.) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Ilaria LaudadioDepartment of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy ilaria.laudadio@uniroma1.it.ORCID 0000-0002-0990-3201
Francesca OrsoDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, Turin, Italy.
Gianluca AzzalinDepartment of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
Carlo CalabròDepartment of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
Francesco BerardinelliDepartment of Science, University of Rome "Roma Tre", Rome, Italy.
Elisa ColuzziDepartment of Science, University of Rome "Roma Tre", Rome, Italy.
Silvia GioiosaCNR, Istituto di Biomembrane, Bioenergetica e Biotecnologie Molecolari (IBIOM), Bari, Italy.
Daniela TavernaDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, Turin, Italy.
Antonella SguraDepartment of Science, University of Rome "Roma Tre", Rome, Italy.
Claudia CarissimiDepartment of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
Valerio FulciDepartment of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
Sapienza University of Rome · ITRoma Tre University · ITUniversity of Turin · ITInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) constitute the core telomerase enzyme that maintains the length of telomeres. Telomere maintenance is affected in a broad range of cancer and degenerative disorders. Taking advantage of gain- and loss-of-function approaches, we show that Argonaute 2 (AGO2) promotes telomerase activity and stimulates the association between TERT and TERC AGO2 depletion results in shorter telomeres as well as in lower proliferation rates

Indexed as

AnimalsArgonaute ProteinsCell Line, TumorCell ProliferationDisease Models, AnimalEnzyme ActivationGene ExpressionGenetic LociHeterograftsHumansMiceNeoplasmsNucleic Acid ConformationProtein BindingRNATelomeraseAGO2 protein, humanArgonaute ProteinsRNATelomerasetelomerase RNATERT protein, humanArgonautecancernon‐coding RNAtelomerasetelomere

Identifiers

PMID30591524
PMCPMC6362350
OpenAlexW2906804826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.