Evidence map›Paper›PMID 30591513›Full record

ArticleThe Journal of cell biology2019

A high-avidity biosensor reveals plasma membrane PI(3,4)P

Brady D Goulden, Jonathan Pacheco, Allyson Dull, James P Zewe, Alexander Deiters, Gerald R V Hammond

Open access · hybridAbstract read
In one paragraph

Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 140 citations in OpenAlex.

  1. PI(3,5)PScience advances · 2026
    Article
  2. Quantitative comparison of PI(3,5)PMolecular biology of the cell · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Subcellular Cartography of the Phosphoinositide Multiverse.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2026
    Review
  11. Article
  12. Quantitative comparison of PI(3,5)PbioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brady D GouldenDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA.ORCID 0000-0002-1954-2091
Jonathan PachecoDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Allyson DullDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
James P ZeweDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Alexander DeitersDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA.
Gerald R V HammondDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA ghammond@pitt.edu.ORCID 0000-0002-6660-3272
University of Pittsburgh · US

Funding

Directing Membrane Function with Inositol Lipids in Health and DiseaseR35GM119412 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gerald R Hammond · 2016 to 2026
$4.3M
NIGMS NIH HHS R35 GM119412
6 · The paper itself

Abstract

Class I phosphoinositide 3-OH kinase (PI3K) signaling is central to animal growth and metabolism, and pathological disruption of this pathway affects cancer and diabetes. However, the specific spatial/temporal dynamics and signaling roles of its minor lipid messenger, phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P

Indexed as

Biosensing TechniquesSignal TransductionAnimalsCell MembraneChlorocebus aethiopsCOS CellsHeLa CellsHumansPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPTEN Phosphohydrolasephosphatidylinositol 3,4-diphosphatePhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPTEN PhosphohydrolasePTEN protein, human

Identifiers

PMID30591513
PMCPMC6400549
OpenAlexW2908359717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.