ArticleMolecular metabolism2019
The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle.
Open access · goldAbstract read
In one paragraph
Article in Molecular metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 116 citations in OpenAlex.
- Effects of exercise in a fed or fasted state on mitochondrial dynamics regulators in the skeletal muscle of recreationally active males.Experimental physiology · 2026Trial
- Aerobic Exercise Attenuates High-Fat Diet-Induced Skeletal Muscle Atrophy by Suppressing Oxidative Stress, Inflammation, and Drp1-Associated Mitochondrial Fission.Antioxidants (Basel, Switzerland) · 2026Article
- Exercise as a Programmable Regulator of Mitophagy Sensitivity in Aging Muscle and Age-Related Disease.IUBMB life · 2026Review
- Systems modelling of mitochondrial dynamics in different exercise regimes.The Journal of physiology · 2026Article
- Exercise Regulates Mitochondrial Quality Control: Maintenance and Remodeling of Skeletal Muscle Homeostasis.Biology · 2026Review
- Review
- Drp1 regulates mitochondrial health and controls skeletal muscle mass through the Erk1/2-Nur77 pathway.Science advances · 2026Article
- Exercise-mediated regulation of mitochondrial dynamics in aging muscle: implications for mitochondrial diseases.Molecular and cellular biochemistry · 2026Review
- Intermittent AP-1 activation in muscles contributes to exercise-induced health benefits.bioRxiv : the preprint server for biology · 2026Article
- Role of exercise in cardiovascular health: a narrative review from prevention to therapeutic utilizations.Frontiers in cardiovascular medicine · 2026Review
- The Role of Exercise in Fat Oxidation and Its Impact on Adolescent Metabolism.Advances in experimental medicine and biology · 2026Review
- The effect of integrative neuromuscular training on physical fitness and punching performance in highly-trained male boxers.Frontiers in physiology · 2026Article
- The role of exercise-mediated mitochondrial quality control remodeling in aging.Frontiers in cell and developmental biology · 2026Review
- Effects of Combined Exercise Training on Modulating Fine Particulate Matter-Induced Skeletal Muscle Damage in Offspring Gestationally Exposed.Journal of cachexia, sarcopenia and muscle · 2025Article
- Resilience of the mitochondrial reticulum in aging.American journal of physiology. Endocrinology and metabolism · 2025Article
- Adaptations in Mitochondrial Function Induced by Exercise: A Therapeutic Route for Treatment-Resistant Depression.International journal of molecular sciences · 2025Review
- Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity.Nature communications · 2025Article
- A constricted mitochondrial morphology formed during respiration.Nature communications · 2025Article
- Loss of ovarian function prevents exercise-induced activation of hepatic mitophagic flux.American journal of physiology. Endocrinology and metabolism · 2025Article
- Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males.Cell reports. Medicine · 2025Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 4 institutions in 2 countries.
Timothy M MooreDepartment of Biological Sciences, Dana & David Dornsife College of Letters, Arts, and Sciences, University of Southern California, CA 90089-0372, USA; David Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Zhenqi ZhouDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Whitaker CohnDavid Geffen School of Medicine, Department of Psychiatry and Biobehavioral Sciences, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA.
Frode NorheimDavid Geffen School of Medicine, Human Genetics, University of California, Los Angeles, CA 90095, USA.
Amanda J LinDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Nareg KalajianDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Alexander R StrumwasserDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Kevin CoryDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Kate WhitneyDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Theodore HoDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Timothy HoDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Joseph L LeeDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Daniel H RuckerDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Orian ShirihaiDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Alexander M van der BliekDavid Geffen School of Medicine, Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA.
Julian P WhiteleggeDavid Geffen School of Medicine, Department of Psychiatry and Biobehavioral Sciences, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA.
Marcus M SeldinDavid Geffen School of Medicine, Human Genetics, University of California, Los Angeles, CA 90095, USA.
Aldons J LusisDavid Geffen School of Medicine, Human Genetics, University of California, Los Angeles, CA 90095, USA; David Geffen School of Medicine, Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.
Sindre LeeUniversity Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Christian A DrevonUniversity Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Sushil K MahataVA San Diego Healthcare System, San Diego, CA 92161, USA; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Lorraine P TurcotteDepartment of Biological Sciences, Dana & David Dornsife College of Letters, Arts, and Sciences, University of Southern California, CA 90089-0372, USA.
Andrea L HevenerDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA; Iris Cantor-UCLA Women's Health Research Center, Los Angeles, CA 90095, USA. Electronic address: ahevener@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of Oslo · NOUniversity of Southern California · USUniversity of California San Diego · US
Funding
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TONTONOZ, PETER J · 1985 to 2019
$55.2MSystems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 1985 to 2019
$50.2MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALAN R. SALTIEL · 2003 to 2026
$40.4MTraining and education CoreU54AR052646 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MCNALLY, ELIZABETH M, SWEENEY, H LEE · 2005 to 2020
$24.1MUCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2017
$9.8MEXPANSION OF NURSA TRANSCRIPTOMINE ANNOTATIONU24DK097748 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI EVANS, RONALD M, MCKENNA, NEIL · 2012 to 2017
$9.2MSex Differences in the Metabolic SyndromeU54DK120342 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 2018 to 2022
$7.6MMuscle Cell Biology, Pathophysiology, and TherapeuticsT32AR065972 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Rachelle Hope Crosbie, THOMAS A. RANDO · 2016 to 2026
$3.9MNeuroendocrinology, Sex Differences, and ReproductionT32HD007228 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P · 1985 to 2015
$3.9MMechanisms controlling skeletal muscle mitochondrial function and metabolic healthR01DK109724 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HEVENER, ANDREA L · 2016 to 2020
$2.4MTraining in Molecular, Cellular &Integrative PhysiologyT32GM065823 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2003 to 2017
$2.1MBLRD VA I01 BX000323BLRD VA I01 BX003934NCATS NIH HHS UL1 TR000124NHLBI NIH HHS P01 HL028481NHLBI NIH HHS P01 HL030568NIAMS NIH HHS T32 AR065972NIAMS NIH HHS U54 AR052646NIA NIH HHS P30 AG028748NICHD NIH HHS T32 HD007228NIDDK NIH HHS F31 DK108657NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK099618NIDDK NIH HHS R01 DK109724NIDDK NIH HHS U24 DK097748NIDDK NIH HHS U54 DK120342NIGMS NIH HHS T32 GM065823NIGMS NIH HHS U01 GM109764
Abstract
objectiveMitochondria are organelles primarily responsible for energy production, and recent evidence indicates that alterations in size, shape, location, and quantity occur in response to fluctuations in energy supply and demand. We tested the impact of acute and chronic exercise on mitochondrial dynamics signaling and determined the impact of the mitochondrial fission regulator Dynamin related protein (Drp)1 on exercise performance and muscle adaptations to training.
methodsWildtype and muscle-specific Drp1 heterozygote (mDrp1
resultsEndurance exercise impacted all aspects of the mitochondrial life cycle, i.e. fission-fusion, biogenesis, and mitophagy. Dnm1L gene expression and Drp1
conclusionOur findings highlight the importance of mitochondrial dynamics, specifically Drp1 signaling, in the regulation of exercise performance and adaptations to endurance exercise training.
Indexed as
Physical Functional PerformanceAdaptation, PhysiologicalAdultAgedAnimalsBlood GlucoseDynaminsFemaleGene DeletionGTP PhosphohydrolasesHumansMaleMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLBlood GlucoseDNM1L protein, humanDnm1l protein, mouseDynaminsGTP PhosphohydrolasesMicrotubule-Associated ProteinsMitochondrial ProteinsDrp1Exercise performanceExercise trainingMitochondrial dynamics
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.