Evidence map›Paper›PMID 30591184›Full record

ReviewTrends in biotechnology2019

Primary Cell-Derived Intestinal Models: Recapitulating Physiology.

Johanna S Dutton, Samuel S Hinman, Raehyun Kim, Yuli Wang, Nancy L Allbritton

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 123 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. AnBiofabrication · 2025
    Article
  8. Review
  9. Review
  10. A simple, efficient technique to make colon crypt gels for 3D models.3D printing and additive manufacturing · 2025
    Article
  11. High-throughput assay for predicting diarrhea risk using a 2D human intestinal stem cell-derived model.Toxicology in vitro : an international journal published in association with BIBRA · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. In Vitro Models for Investigating Intestinal Host-Pathogen Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Johanna S DuttonJoint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, and North Carolina State University, Raleigh, NC, USA.
Samuel S HinmanDepartment of Chemistry, University of North Carolina, Chapel Hill, NC, USA.
Raehyun KimJoint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, and North Carolina State University, Raleigh, NC, USA.
Yuli WangDepartment of Chemistry, University of North Carolina, Chapel Hill, NC, USA.
Nancy L AllbrittonJoint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, and North Carolina State University, Raleigh, NC, USA; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA. Electronic address: nlallbri@unc.edu.
University of North Carolina at Chapel Hill · USNorth Carolina State University · US

Funding

DEVELOPMENT OF HUMAN INTESTINAL SIMULACRAR01DK109559 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ALLBRITTON, NANCY L., BULTMAN, SCOTT J · 2015 to 2019
$5.2M
NIDDK NIH HHS R01 DK109559
6 · The paper itself

Abstract

The development of physiologically relevant intestinal models fueled by breakthroughs in primary cell-culture methods has enabled successful recapitulation of key features of intestinal physiology. These advances, paired with engineering methods, for example incorporating chemical gradients or physical forces across the tissues, have yielded ever more sophisticated systems that enhance our understanding of the impact of the host microbiome on human physiology as well as on the genesis of intestinal diseases such as inflammatory bowel disease and colon cancer. In this review we highlight recent advances in the development and usage of primary cell-derived intestinal models incorporating monolayers, organoids, microengineered platforms, and macrostructured systems, and discuss the expected directions of the field.

Indexed as

Models, BiologicalCell Culture TechniquesCells, CulturedHumansIntestinesOrganoidsTissue Engineeringintestinein vitro modelsmonolayersorganoidsorgan-on-chipsstem cells

Identifiers

PMID30591184
PMCPMC6571163
OpenAlexW2906590646

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.