Evidence map›Paper›PMID 30591083›Full record

ArticleCNS spectrums2019

Cognitive impairment in substance use disorders.

Tatiana Ramey, Paul S Regier

Abstract read
In one paragraph

Article in CNS spectrums, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Working Memory Training Reduces Cigarette Smoking Among Low-Income Individuals With Elevated Delay Discounting.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Trial
  6. Article
  7. Article
  8. Article
  9. Review
  10. Addiction and chronic skin diseases: A Pan-European study on prevalence, associations and patient impact.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Disinhibition of ventral tegmental area during initial punishment learning causes enduring punishment insensitivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  15. Comorbid HIV and Cocaine Use Exacerbate Accelerated Brain Aging.bioRxiv : the preprint server for biology · 2026
    Article
  16. Article
  17. Innovations to improve outcomes and uptake of psychotherapies for mental disorders: a state-of-the-art review.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article
  18. Article
  19. Article
  20. Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tatiana RameyDivision of Therapeutics and Medical Consequences, National Institute on Drug Abuse, National Institutes of Health, Rockville, Maryland.ORCID https://orcid.org/0000-0002-1909-2385
Paul S RegierCenter for Studies of Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Funding

Center for the Development of Novel Medications for Cocaine DependenceU54DA039002 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KAMPMAN, KYLE MATTHEW · 2014 to 2018
$5.1M
T32 Translational Addiction Research Fellowship ProgramT32DA028874 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Julie A Blendy, Anna Rose Childress · 2010 to 2026
$5.0M
Targeting dopamine D3 receptors in cocaine addictionR01DA039215 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI CHILDRESS, ANNA ROSE · 2016 to 2019
$2.5M
Intramural NIH HHS Z99 DA999999NIDA NIH HHS R01 DA039215NIDA NIH HHS T32 DA028874NIDA NIH HHS U54 DA039002
6 · The paper itself

Abstract

Cognitive impairments in substance use disorders have been extensively researched, especially since the advent of cognitive and computational neuroscience and neuroimaging methods in the last 20 years. Conceptually, altered cognitive function can be viewed as a hallmark feature of substance use disorders, with documented alterations in the well-known "executive" domains of attention, inhibition/regulation, working memory, and decision-making. Poor cognitive (sometimes referred to as "top-down") regulation of downstream motivational processes-whether appetitive (reward, incentive salience) or aversive (stress, negative affect)-is recognized as a fundamental impairment in addiction and a potentially important target for intervention. As addressed in this special issue, cognitive impairment is a transdiagnostic domain; thus, advances in the characterization and treatment of cognitive dysfunction in substance use disorders could have benefit across multiple psychiatric disorders. Toward this general goal, we summarize current findings in the abovementioned cognitive domains of substance use disorders, while suggesting a potentially useful expansion to include processes that both precede (precognition) and supersede (social cognition) what is usually thought of as strictly cognition. These additional two areas have received relatively less attention but phenomenologically and otherwise are important features of substance use disorders. The review concludes with suggestions for research and potential therapeutic targeting of both the familiar and this more comprehensive version of cognitive domains related to substance use disorders.

Indexed as

Attentiondecision-makingexecutive functioninhibitionmetacognitionprecognitionsocial cognitionsubstance use disorderstheory of mindworking memory

Identifiers

PMID30591083
PMCPMC6599555

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.