Evidence map›Paper›PMID 30591080›Full record

ArticleActa neuropathologica communications2018

A functional genomics approach to identify pathways of drug resistance in medulloblastoma.

Kelsey C Bertrand, Claudia C Faria, Patryk Skowron, Amanda Luck, Livia Garzia, Xiaochong Wu, Sameer Agnihotri, Christian A Smith, Michael D Taylor, Stephen C Mack and 1 more

Abstract readLetter
In one paragraph

Article in Acta neuropathologica communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. The molecular biology of medulloblastoma metastasis.Brain pathology (Zurich, Switzerland) · 2020
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kelsey C BertrandDepartment of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, USA.
Claudia C FariaDepartment of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal.
Patryk SkowronDepartment of Developmental and Stem Cell Biology and Regenerative Medicine, The Hospital for Sick Children, Toronto, Canada.
Amanda LuckDepartment of Developmental and Stem Cell Biology and Regenerative Medicine, The Hospital for Sick Children, Toronto, Canada.
Livia GarziaDepartment of Developmental and Stem Cell Biology and Regenerative Medicine, The Hospital for Sick Children, Toronto, Canada.
Xiaochong WuDepartment of Developmental and Stem Cell Biology and Regenerative Medicine, The Hospital for Sick Children, Toronto, Canada.
Sameer AgnihotriDepartment of Neurological Surgery, Children's Hospital, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Christian A SmithDepartment of Developmental and Stem Cell Biology and Regenerative Medicine, The Hospital for Sick Children, Toronto, Canada.
Michael D TaylorDepartment of Developmental and Stem Cell Biology and Regenerative Medicine, The Hospital for Sick Children, Toronto, Canada.
Stephen C MackDepartment of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, USA. stephen.mack@bcm.edu.ORCID 0000-0001-9620-4742
James T RutkaDepartment of Developmental and Stem Cell Biology and Regenerative Medicine, The Hospital for Sick Children, Toronto, Canada. james.rutka@sickkids.ca.

Funding

Mouse models to discover new drivers of medulloblastomaR01CA159859 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael D. Taylor, WILLIAM A WEISS · 2011 to 2026
$10.4M
Medulloblastoma and MetastasesR01CA148699 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TAYLOR, MICHAEL D., WEISS, WILLIAM A · 2010 to 2014
$2.4M
Roles of Epstein-Barr virus nuclear antigens 2 and LP in B cell proliferationR01CA170023 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHAO, BO · 2013 to 2017
$1.9M
Canadian Cancer Society Research Institute 2011-70051Cancer Prevention and Research Institute of Texas RR170023NCI NIH HHS R01 CA148699NCI NIH HHS R01CA148699NCI NIH HHS R01 CA159859NIH HHS R01CA159859
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnilidesAnimalsCerebellar NeoplasmsDisease Models, AnimalDrug Delivery SystemsDrug Resistance, NeoplasmGene Regulatory NetworksGenomicsHumansMedulloblastomaMiceMice, TransgenicMutationPatched-1 ReceptorQuinolinesSignal TransductionAnilidesGSK 1363089Patched-1 ReceptorPTCH1 protein, humanQuinolinessleeping beauty transposase, humanTransposasesBrain tumorCancerDrug resistanceFunctional genomicsMedulloblastomaSleeping beautyTransposon mutagenesis

Identifiers

PMID30591080
PMCPMC6307130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.