ArticleBMC medicine2018
The SMILES trial: do undisclosed recruitment practices explain the remarkably large effect?
Article in BMC medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- History repeating: guidelines to address common problems in psychedelic science.Therapeutic advances in psychopharmacology · 2023Review
- Lipids in major depressive disorder: new kids on the block or old friends revisited?Frontiers in psychiatry · 2023Review
- Mental Health Symptom Reduction Using Digital Therapeutics Care Informed by Genomic SNPs and Gut Microbiome Signatures.Journal of personalized medicine · 2022Article
- There is not much to mediate [yet] when it comes to diet and depression.Molecular psychiatry · 2022Article
- Exploring the Impact of Flavonoids on Symptoms of Depression: A Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2021Review
- Article
- Diet, Stress and Mental Health.Nutrients · 2020Review
- Article
- Linking What We Eat to Our Mood: A Review of Diet, Dietary Antioxidants, and Depression.Antioxidants (Basel, Switzerland) · 2019Review
- Review
- Diet quality and depression risk in a Japanese population: the Japan Public Health Center (JPHC)-based Prospective Study.Scientific reports · 2019Article
- The SMILES trial: an important first step.BMC medicine · 2018Article
- Magnesium and mood disorders: systematic review and meta-analysis.BJPsych open · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SMILES trial showed substantial improvement of depressive symptoms following seven consultations on healthy dieting. The very large effect size on depression reduction seems remarkable and we suggest that selectively induced expectancy and a loss of blinding have contributed to the observed effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.