ArticleJournal of neuropathology and experimental neurology2019
A Quantitative Study of Empty Baskets in Essential Tremor and Other Motor Neurodegenerative Diseases.
Article in Journal of neuropathology and experimental neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 26 citations in OpenAlex.
- Purkinje Cell Loss and Changes in Basket Cell Morphology in Essential Tremor and Other Cerebellar Degenerative Diseases: A Postmortem Study of 332 Brains.Cerebellum (London, England) · 2026Article
- Autopsy-Confirmed Non-Paraneoplastic Lambert-Eaton Myasthenic Syndrome with Cerebellar Degeneration: A Case Report.Diagnostics (Basel, Switzerland) · 2026Article
- An Investigation of Heterogeneity in Cerebellar Cortical Pathology Across Essential Tremor Cases: A Cluster Analysis.Cerebellum (London, England) · 2026Article
- Essential Tremor Cases with Subtle Cerebellar Pathology: A Systematic Study of Postmortem Cerebellar Changes.Cerebellum (London, England) · 2026Article
- Comparative study of the pathology in anterior versus posterior hemispheric regions of cerebellum in essential tremor and controls.Acta neuropathologica · 2026Article
- Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21-Year Period.Annals of clinical and translational neurology · 2026Article
- Loss-of-function variations in solute carrier family 38 member 6 are associated with essential tremor.Signal transduction and targeted therapy · 2025Article
- Axonal pathology differentially affects human Purkinje cell subpopulations in the essential tremor cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Axonal pathology differentially affects human Purkinje cell subtypes in the essential tremor cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Purkinje Cell Dendritic Swellings: A Postmortem Study of Essential Tremor and Other Cerebellar Degenerative Disorders.Cerebellum (London, England) · 2024Article
- Neuroprotection of low dose carbon monoxide in Parkinson's disease models commensurate with the reduced risk of Parkinson's among smokers.NPJ Parkinson's disease · 2024Article
- Pathologically based criteria to distinguish essential tremor from controls: analyses of the human cerebellum.Annals of clinical and translational neurology · 2024Article
- Exploring White Matter Microstructure with Symptom Severity and Outcomes Following Deep Brain Stimulation in Tremor Syndromes.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Gene Expression Analysis of Laser-Captured Purkinje Cells in the Essential Tremor Cerebellum.Cerebellum (London, England) · 2023Article
- Histopathology of the cerebellar cortex in essential tremor and other neurodegenerative motor disorders: comparative analysis of 320 brains.Acta neuropathologica · 2023Article
- Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder.International review of neurobiology · 2022Article
- Essential Tremor versus "ET-plus": A Detailed Postmortem Study of Cerebellar Pathology.Cerebellum (London, England) · 2021Article
- Essential tremor.Nature reviews. Disease primers · 2021Review
- Article
- Gene expression analysis of the cerebellar cortex in essential tremor.Neuroscience letters · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The underlying biology of essential tremor (ET) is poorly understood. Purkinje cell (PC) loss has been observed in some studies, although this finding remains somewhat controversial. Basket cells are interneurons whose axonal collaterals form a plexus around PC soma. When there is PC loss, this basket plexus appears empty. We used dual immunohistochemical staining for calbindin D28k and glutamic acid decarboxylase to quantify "empty baskets" as an indirect and alternative method of detecting PC loss. Microscopic analyses on 127 brains included ET and a spectrum of motor neurodegenerative diseases (50 ET, 27 spinocerebellar ataxias [SCAs], 25 Parkinson disease, 25 controls). The median percentage of empty baskets in ET patients was 1.5 times higher than controls (48.8% vs 33.5%, p < 0.001) but lower in ET than in SCA1 (59.7%, p = 0.011), SCA2 (77.5%, p = 0.003), and SCA6 (87.0%, p < 0.001). PC loss is not a feature of SCA3, and the median percentage of empty baskets (30.1%) was similar to controls (p = 0.303). These data provide support for PC loss in ET and are consistent with the notion that ET could represent a mild form of cerebellar degeneration with an intermediate degree of PC loss.
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Registered trials
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