ArticleThe Journal of clinical endocrinology and metabolism2019
Pre-Conception Characteristics Predict Obstetrical and Neonatal Outcomes in Women With Polycystic Ovary Syndrome.
Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06064669 (Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus), which is not on this map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Different supplements improve insulin resistance, hormonal functions, and oxidative stress on overweight and obese women with polycystic ovary syndrome: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Progress of the application clinical prediction model in polycystic ovary syndrome.Journal of ovarian research · 2023Pooled it
- Cardiometabolic health in offspring of women with PCOS compared to healthy controls: a systematic review and individual participant data meta-analysis.Human reproduction update · 2020Pooled it
- Hyperandrogenism Synergizes With Obesity to Increase the Risk of Hypertensive Disorders of Pregnancy After Frozen Embryo Transfer.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Distinct pregnancy challenges in PCOS women undergoing IVF/ICSI with singleton and twin births: a propensity-matched analysis.Journal of ovarian research · 2026Article
- Genetically Predicted Causal Relationship Between Polycystic Ovary Syndrome and Preeclampsia.International journal of endocrinology · 2026Article
- Reproductive prognosis factors in women with infertility and polycystic ovary syndrome undergoing in vitro fertilization techniques.JBRA assisted reproduction · 2025Article
- Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective.Annals of medicine · 2025Review
- Utero-placental (vascular) development throughout pregnancy in women with polycystic ovary syndrome: the Rotterdam Periconceptional Cohort.F&S reports · 2025Article
- Adverse Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome with Pre-Conceptional Hyperandrogenism: A Multi-Institutional Registry-Based Retrospective Cohort Study.Journal of clinical medicine · 2024Article
- Pre-Conception Androgen Levels and Obstetric Outcomes in Polycystic Ovary Syndrome: A Single-Center Retrospective Study.Diagnostics (Basel, Switzerland) · 2024Article
- Growth Restriction in the Offspring of Mothers With Polycystic Ovary Syndrome.JAMA network open · 2024Article
- Pregnancy, delivery, and neonatal outcomes among women with PCOS and endometriosis: a population database cohort.Archives of gynecology and obstetrics · 2024Article
- Preparation of the endometrium for frozen embryo transfer: an update on clinical practices.Reproductive biology and endocrinology : RB&E · 2023Review
- Current Guidelines for Diagnosing PCOS.Diagnostics (Basel, Switzerland) · 2023Review
- Treatments in Patients with Polycystic Ovary Syndrome and Effects on Kisspeptin Serum Levels.Maedica · 2022Article
- PCOS and the risk of pre-eclampsia.Reproductive biomedicine online · 2022Article
- The impact of hyperandrogenism on the outcomes of ovulation induction using gonadotropin and intrauterine insemination in women with polycystic ovary syndrome.Clinical and experimental reproductive medicine · 2022Article
- Effect of artificial cycle with or without GnRH-a pretreatment on pregnancy and neonatal outcomes in women with PCOS after frozen embryo transfer: a propensity score matching study.Reproductive biology and endocrinology : RB&E · 2022Article
- Polycystic Ovarian Syndrome: A Complex Disease with a Genetics Approach.Biomedicines · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Context: Women with polycystic ovary syndrome (PCOS) are at increased risk for obstetric and perinatal complications. At present, it is unknown how characteristics of PCOS relate to the likelihood of these complications. Objective: To evaluate which preconception features are associated with obstetric and perinatal disease among infertile women with PCOS. Design: Data from two prospective cohort studies completed from January 2004 until January 2014 were linked to Dutch Perinatal national registry outcomes. Setting: Two Dutch university medical centers. Participants: 2768 women diagnosed with PCOS were included. Participants underwent an extensive standardized preconception screening. Exclusion criteria included: age <18 years or >45 years, language barrier, or failure to meet PCOS criteria. Interventions: None. Main Outcome Measures: Outcome measures were obtained from the Dutch Perinatal national registry and included: preeclampsia, preterm delivery, small for gestational age (SGA), low Apgar score, and any adverse outcome. Results: 1715 (62% of participants) women with PCOS were identified as undergoing a pregnancy with live birth after screening. In fully adjusted models, prepregnancy free androgen index was associated with subsequent preeclampsia [OR (95% CI), 1.1 (1.0 to 1.1)]. Fasting glucose [1.4 (1.2 to 1.7)] and testosterone [1.5 (1.2 to 1.7)] predicted preterm delivery. Fasting insulin [1.003 (1.001 to 1.005)], and testosterone [1.2 (1.1 to 1.4)] predicted any adverse outcome. SGA was only predicted by features nonspecific to PCOS. Conclusions: Primary disease characteristics of PCOS, chiefly hyperandrogenism and impaired glucose tolerance, predict suboptimal obstetric and neonatal outcomes. Increased surveillance during pregnancy should focus on women with PCOS and these features to help mitigate disease risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.