ArticleEuropean heart journal2020
Composition of nocturnal hypoxaemic burden and its prognostic value for cardiovascular mortality in older community-dwelling men.
Article in European heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00070681 (Outcomes of Sleep Disorders in Older Men), which is not on this map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Outcomes of Sleep Disorders in Older Men
Who cites it
55 citing papers in PubMed.
- The effect of short-term descent to low altitude in healthy residents at moderate altitude - a randomized crossover trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Trial
- Hypoxaemic burden in heart failure patients receiving adaptive servo-ventilation.ESC heart failure · 2023Trial
- Trial
- Improving Nocturnal Hypoxemic Burden with Transvenous Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea.Journal of cardiovascular translational research · 2021Trial
- Trial
- Correlation of hypoxic burden with blood pressure diurnal rhythm in obstructive sleep apnea.Sleep · 2026Article
- Association Between Nocturnal Oxygen Desaturation and the Severity of Obstructive Sleep Apnea: A Retrospective Study.Cureus · 2026Article
- Modified Sleep Apnea Severity Index and Cardiovascular Risk in CPAP-Intolerant OSA Patients.The Laryngoscope · 2026Article
- Sleep Apnea-Specific Hypoxic Burden and Postoperative Outcomes of Major Noncardiothoracic Surgery.JAMA network open · 2026Observational
- Comparison of oxygen desaturation area-based methods in predicting cardiovascular disease-related mortality outcomes.Frontiers in network physiology · 2026Article
- Nighttime Respiratory Disturbance and Hypoxemia Associated with Impaired Linear Growth in Children with Obstructive Sleep Apnea.Nature and science of sleep · 2026Article
- Effect Heterogeneity of CPAP on MACE by Nocturnal Hypoxia Burden in Older Adults OSAS: A Propensity Score Matching Study.Clinical interventions in aging · 2026Article
- Hypoxemia burden and atherogenic indices in OSAS: changes after CPAP therapy.Frontiers in medicine · 2026Article
- Article
- Risk assessment and prevention of cardiovascular events in patients with obstructive sleep apnea syndrome: A narrative review.International journal of cardiology. Cardiovascular risk and prevention · 2025Review
- Nocturnal hypoxemic burden is associated with worsening prognosis of chronic kidney disease in patients with type 2 diabetes.Cardiovascular diabetology · 2025Observational
- Patent foramen ovale (PFO) exacerbates intermittent hypoxia in moderate-to-severe obstructive sleep apnea (OSA) patients.Sleep & breathing = Schlaf & Atmung · 2025Article
- Prognostic value of hypoxaemic burden from overnight oximetry in heart failure with preserved ejection fraction.ESC heart failure · 2025Article
- Sleep-disordered breathing increases mortality in patients with diabetes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Observational
- Revisiting Transvenous Phrenic Nerve Stimulation in Central Sleep Apnoea and Heart Failure: Emerging Innovations in Clinical Trials Analysis.Cardiac failure review · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
aimsTo investigate the composition of nocturnal hypoxaemic burden and its prognostic value for cardiovascular (CV) mortality in community-dwelling older men. METHODS AND
resultsWe analysed overnight oximetry data from polysomnograms obtained in 2840 men from the Outcomes of Sleep Disorders in Older Men (MrOS Sleep) study (ClinicalTrials.gov Identifier: NCT00070681) to determine the number of acute episodic desaturations per hour (oxygen desaturation index, ODI) and time spent below 90% oxygen saturation (T90) attributed to acute desaturations (T90desaturation) and to non-specific drifts in oxygen saturation (T90non-specific), respectively, and their relationship with CV mortality. After 8.8 ± 2.7 years follow-up, 185 men (6.5%) died from CV disease. T90 [hazard ratio (HR) 1.21, P < 0.001], but not ODI (HR 1.13, P = 0.06), was significantly associated with CV death in univariate analysis. T90 remained significant when adjusting for potential confounders (HR 1.16, P = 0.004). Men with T90 > 12 min were at an elevated risk of CV mortality (HR 1.59; P = 0.006). Approximately 20.7 (5.7-48.5) percent of the variation in T90 could be attributed to non-specific drifts in oxygen saturation. T90desaturation and T90non-specific were individually associated with CV death but combining both variables did not improve the prediction.
conclusionIn community-dwelling older men, T90 is an independent predictor of CV mortality. T90 is not only a consequence of frank desaturations, but also reflects non-specific drifts in oxygen saturation, both contributing towards the association with CV death. Whether T90 can be used as a risk marker in the clinical setting and whether its reduction may constitute a treatment target warrants further study.
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