ArticleAmerican journal of epidemiology2019
Counterpoint: Mediation Formulas With Binary Mediators and Outcomes and the "Rare Outcome Assumption".
Article in American journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Social determinants of health andFrontiers in public health · 2025Pooled it
- Time-Varying Mediation of Pharmacological Smoking Cessation Treatments on Smoking Lapse via Craving, Cessation Fatigue, and Negative Mood.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Trial
- The role of cardiovascular disease as a mediator in mitigating the impact of ambient PMEnvironmental epidemiology (Philadelphia, Pa.) · 2025Article
- First stage of labour duration and associated risk of adverse neonatal outcomes.Scientific reports · 2023Article
- Family resilience and neighborhood factors affect the association between digital media use and mental health among children: does sleep mediate the association?European journal of pediatrics · 2023Article
- Discussing reproductive goals with healthcare providers among women living with HIV in Canada: the role of provider gender and patient comfort.Sexual and reproductive health matters · 2021Article
- Mediation analysis methods used in observational research: a scoping review and recommendations.BMC medical research methodology · 2021Article
- Parametric-Regression-Based Causal Mediation Analysis of Binary Outcomes and Binary Mediators: Moving Beyond the Rareness or Commonness of the Outcome.American journal of epidemiology · 2021Article
- Invited Commentary: Frontiers of Power Assessment in Mediation Analysis.American journal of epidemiology · 2020Article
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Authors and funding
3 authors.
Funding
Abstract
In their accompanying article, Samoilenko and Lefebvre (Am J Epidemiol. 2019;188(7):1203-1205) correctly note 2 typographical errors in the formulas presented in a 2011 paper on placental abruption by Ananth and VanderWeele (Am J Epidemiol. 2011;174(1):99-108). Fortunately, to the best of our knowledge, researchers are using our methods papers and Dr. VanderWeele's 2015 book on mediation analysis (Explanation in Causal Inference; Oxford University Press, New York, New York), rather than the paper on placental abruption, to carry out their direct and indirect effect analyses; and in our methods papers and the book, the formulas are correct. The formulas discussed by Samoilenko and Lefebvre and in our work make reference to a "rare outcome assumption." In evaluating this assumption, it is important to note that the outcome is to be relatively rare across all strata defined by the exposure and the mediator-a point that is often neglected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.