ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Anticholinergic Drug Induced Cognitive and Physical Impairment: Results from the InCHIANTI Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Artificial Intelligence in Pharmacoepidemiology: A Systematic Review. Part 1-Overview of Knowledge Discovery Techniques in Artificial Intelligence.Frontiers in pharmacology · 2020Pooled it
- Multifactorial analysis of risk factors for frailty and cognitive frailty among hospitalized patients.BMC geriatrics · 2026Article
- Medication Use by Older Adults with Frailty: A Scoping Review.Pharmacy (Basel, Switzerland) · 2025Review
- Anticholinergic drug exposure is associated with prevalence, worsening and incidence of dysphagia among hospitalized older adults.The journal of nutrition, health & aging · 2025Article
- The relationship between anticholinergic drug burden and clinical frailty in urinary incontinence patients.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Exploring the impact of anticholinergic burden on urinary independence: insights from a post-stroke cohort of older adults.International journal of clinical pharmacy · 2024Observational
- Medication use quality and safety in older adults: 2022 update.Journal of the American Geriatrics Society · 2024Review
- Increased anticholinergic medication use in middle-aged and older autistic adults and its associations with self-reported memory difficulties and cognitive decline.Autism research : official journal of the International Society for Autism Research · 2024Article
- Moving towards the detection of frailty with biomarkers: A population health study.Aging cell · 2024Article
- Low-Income Older Adults' Vulnerability to Anticholinergic Medication-Associated Frailty.Drugs & aging · 2023Article
- The A-to-Z factors associated with cognitive impairment. Results of the DeCo study.Frontiers in psychology · 2023Article
- Multimorbidity Clusters in the Oldest Old: Results from the EpiChron Cohort.International journal of environmental research and public health · 2022Article
- Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke.Nutrients · 2022Article
- CRIDECO Anticholinergic Load Scale: An Updated Anticholinergic Burden Scale. Comparison with the ACB Scale in Spanish Individuals with Subjective Memory Complaints.Journal of personalized medicine · 2022Article
- Anticholinergic Medication Burden in Parkinson's Disease Outpatients.Journal of Parkinson's disease · 2022Article
- Antimuscarinic Anticholinergic Medications in Parkinson Disease: To Prescribe or Deprescribe?Movement disorders clinical practice · 2021Review
- Anticholinergic Burden and Safety Outcomes in Older Patients with Chronic Hepatitis C: A Retrospective Cohort Study.International journal of environmental research and public health · 2020Article
- Shared mechanisms for cognitive impairment and physical frailty: A model for complex systems.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Anticholinergic Burden, Sleep Quality and Health Outcomes in Malaysian Aged Care Home Residents.Pharmacy (Basel, Switzerland) · 2019Article
- The relationship between anticholinergic burden and frailty in the year preceding a diagnosis of dementia with Lewy bodies.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe aims of this study were to evaluate the relationship between anticholinergic drug burden (ACB) cognitive impairment, physical frailty, and cognitive frailty, and to determine if ACB is predictive of these phenotypes when modeled with biological and genomic biomarkers.
methodsIn a retrospective cohort study, a total of 1,453 adults aged 20-102 years were used to examine ACB as a predictor for cognitive impairment, physical frailty, and cognitive frailty. Anticholinergic burden is examined as a predictor for all phenotypes in a cross-sectional analysis using logistic, ordinal regression models, and Extreme Gradient Boosting for population predictive modeling.
resultsA significant association was found between ACB and cognitive decline (p = .02), frailty (p < .001), and cognitive frailty (p < .001). The odds of cognitive impairment increased by 1.21 (95% confidence interval [CI] = 1.06-1.37, p < .001), odds of being frail increased by 1.33 (95% CI = 1.18-1.50, p < .001), and odds of having cognitive frailty increased by 1.36 (95% CI = 1.21-1.54, p < .001). Population modeling results indicated ACB score as one of the stronger predictors for cognitive impairment, physical frailty, and cognitive frailty with area under the curves ranging from 0.81 to 0.88.
conclusionsAnticholinergic medications are a potentially modifiable risk factor for the prevention of cognitive and physical decline. Identification of reversible causes for cognitive and physical impairment is critical for the aging population. These findings encourage new research that may lead to effective interventions for deprescribing programs for the prevention of cognitive and physical decline in older adults.
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