Evidence map›Paper›PMID 30590069›Full record

ReviewMolecular and biochemical parasitology2019

Protean permeases: Diverse roles for membrane transport proteins in kinetoplastid protozoa.

Scott M Landfear

Abstract readReview
In one paragraph

Review in Molecular and biochemical parasitology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Evaluation of Beauvericin's activity and mode of action against all life stages ofFrontiers in cellular and infection microbiology · 2025
    Article
  2. Article
  3. Review
  4. Broadening the spectrum of ivermectin: Its effect onFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Scott M LandfearDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, 97239, USA. Electronic address: landfear@ohsu.edu.
Oregon Health & Science University · US

Funding

Function of the Essential KHARON1 Protein in Bloodstream Form African TrypanosomesR01AI121160 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LANDFEAR, SCOTT M · 2016 to 2020
$2.6M
The Role of the Kharon Complex in Leishmania VirulenceR21AI114822 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LANDFEAR, SCOTT M · 2015 to 2016
$424k
Development of Drugs that Target the Malaria Hexose TransporterR21AI114842 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LANDFEAR, SCOTT M · 2015 to 2016
$424k
NIAID NIH HHS R01 AI121160NIAID NIH HHS R21 AI114822NIAID NIH HHS R21 AI114842
6 · The paper itself

Abstract

Kinetoplastid parasites such as Trypanosoma brucei, Trypanosoma cruzi, and Leishmania species rely upon their insect and vertebrate hosts to provide a plethora of nutrients throughout their life cycles. Nutrients and ions critical for parasite survival are taken up across the parasite plasma membrane by transporters and channels, polytopic membrane proteins that provide substrate-specific pores across the hydrophobic barrier. However, transporters and channels serve a wide range of biological functions beyond uptake of nutrients. This article highlights the diversity of activities that these integral membrane proteins serve and underscores the emerging complexity of their functions.

Indexed as

Biological TransportLeishmaniaMembrane ProteinsMembrane Transport ProteinsProtozoan ProteinsTrypanosoma brucei bruceiTrypanosoma cruziMembrane ProteinsMembrane Transport ProteinsProtozoan ProteinsChannelsDrug sensitivityKinetoplastid parasitesOrganellesSensingTransporters

Identifiers

PMID30590069
PMCPMC6415942
OpenAlexW2905954090

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.