Evidence map›Paper›PMID 30589782›Full record

ArticlePlastic and reconstructive surgery2019

Oncologic Safety of Fat Grafting for Autologous Breast Reconstruction in an Animal Model of Residual Breast Cancer.

Mayara M A Silva, Lauren E Kokai, Vera S Donnenberg, Jeffrey L Fine, Kacey G Marra, Albert D Donnenberg, Miguel Sabino Neto, J Peter Rubin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  6. Article
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  8. Article
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  11. Regenerative and stem cell-based techniques for facial rejuvenation.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  12. Review
  13. Article
  14. Frontiers in cell and developmental biology · 2021
    Review
  15. Article
  16. Fat grafts enriched with adipose-derived stem cells.Archives of craniofacial surgery · 2020
    Article
  17. Article
  18. Fat Grafting in Breast Reconstruction.Seminars in plastic surgery · 2020
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mayara M A SilvaFrom the Division of Plastic Surgery, Department of Surgery, Federal University of São Paulo; the Departments of Plastic Surgery, Cardiothoracic Surgery, Pathology, Bioengineering, and Medicine, University of Pittsburgh; the McGowan Institute of Regenerative Medicine; and the University of Pittsburgh Cancer Center.
Lauren E KokaiFrom the Division of Plastic Surgery, Department of Surgery, Federal University of São Paulo; the Departments of Plastic Surgery, Cardiothoracic Surgery, Pathology, Bioengineering, and Medicine, University of Pittsburgh; the McGowan Institute of Regenerative Medicine; and the University of Pittsburgh Cancer Center.
Vera S DonnenbergFrom the Division of Plastic Surgery, Department of Surgery, Federal University of São Paulo; the Departments of Plastic Surgery, Cardiothoracic Surgery, Pathology, Bioengineering, and Medicine, University of Pittsburgh; the McGowan Institute of Regenerative Medicine; and the University of Pittsburgh Cancer Center.
Jeffrey L FineFrom the Division of Plastic Surgery, Department of Surgery, Federal University of São Paulo; the Departments of Plastic Surgery, Cardiothoracic Surgery, Pathology, Bioengineering, and Medicine, University of Pittsburgh; the McGowan Institute of Regenerative Medicine; and the University of Pittsburgh Cancer Center.
Kacey G MarraFrom the Division of Plastic Surgery, Department of Surgery, Federal University of São Paulo; the Departments of Plastic Surgery, Cardiothoracic Surgery, Pathology, Bioengineering, and Medicine, University of Pittsburgh; the McGowan Institute of Regenerative Medicine; and the University of Pittsburgh Cancer Center.
Albert D DonnenbergFrom the Division of Plastic Surgery, Department of Surgery, Federal University of São Paulo; the Departments of Plastic Surgery, Cardiothoracic Surgery, Pathology, Bioengineering, and Medicine, University of Pittsburgh; the McGowan Institute of Regenerative Medicine; and the University of Pittsburgh Cancer Center.
Miguel Sabino NetoFrom the Division of Plastic Surgery, Department of Surgery, Federal University of São Paulo; the Departments of Plastic Surgery, Cardiothoracic Surgery, Pathology, Bioengineering, and Medicine, University of Pittsburgh; the McGowan Institute of Regenerative Medicine; and the University of Pittsburgh Cancer Center.
J Peter RubinFrom the Division of Plastic Surgery, Department of Surgery, Federal University of São Paulo; the Departments of Plastic Surgery, Cardiothoracic Surgery, Pathology, Bioengineering, and Medicine, University of Pittsburgh; the McGowan Institute of Regenerative Medicine; and the University of Pittsburgh Cancer Center.
McGowan Institute for Regenerative Medicine · US

Funding

Injectable Engineered Tissue for Cancer ReconstructionR01CA114246 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RUBIN, J PETER · 2006 to 2019
$3.3M
NCI NIH HHS R01 CA114246
6 · The paper itself

Abstract

backgroundClinical outcomes suggest that postoncologic reconstruction with fat grafting yields cumulative incidence curves of recurrence comparable to those of other breast reconstruction procedures; however, results from experimental research studies suggest that adipose stem cells can stimulate cancer growth. In this study, a novel animal model of residual cancer was developed in mouse mammary pads to test whether lipofilling impacts the probability of locoregional recurrence of breast cancer after breast conserving surgery.

methodsMammary fat pads of female NOD-SCID gamma mice were each injected with MCF-7 cells in Matrigel. Tumors were allowed to engraft for 2 weeks, after which time either sterile saline (n = 20) or human fat graft (n = 20) was injected adjacent to tumor sites. After 8 weeks, tumors were assessed for volume measurement, histologic grade, Ki67 positivity, and metastatic spread.

resultsAnimals receiving lipofilling after tumor cell engraftment had lower tumor volume and mass (p = 0.046 and p = 0.038, respectively). Macroscopic invasion was higher in the saline group. Histologic grade was not significantly different in the two groups (p = 0.17). Ki67 proliferation index was lower in tumors surrounded by fat graft (p = 0.01). No metastatic lesion was identified in any animal.

conclusionsAdipose transfer for breast reconstruction performed in the setting of residual breast tumor in a clinically relevant animal model did not increase tumor size, proliferation, histologic grade, or metastatic spread. This study supports the oncologic safety of lipofilling as part of the surgical platform for breast reconstruction after cancer therapy.

Indexed as

Adipose TissueAnimalsBiopsy, NeedleBreast NeoplasmsDisease Models, AnimalFemaleHeterograftsHumansImmunohistochemistryMammaplastyMammary Neoplasms, ExperimentalMiceMice, Inbred NODMice, SCIDNeoplasm Recurrence, LocalNeoplasm, Residual

Identifiers

PMID30589782
PMCPMC8462977
OpenAlexW2908039227

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.