Trial reportThe journal of trauma and acute care surgery2019
Indocyanine green dye angiography as an adjunct to assess indeterminate burn wounds: A prospective, multicentered, triple-blinded study.
Trial report in The journal of trauma and acute care surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Dual-modality perfusion mapping in a complex pretibial wound: A case report.Trauma case reports · 2026Article
- Optical, Tomographic, and Mass Spectrometry Imaging Methods for Burn Wounds: Capabilities, Limitations, and Clinical Potential.Biomedicines · 2026Review
- The Diagnostic Value of Indocyanine Green in the Assessment of Depth of Burn Injuries: A Systematic Review.European burn journal · 2026Review
- Assessing Burn Depth by Indocyanine Green Angiography: A Systematic Review and Algorithm for Clinical Use.Annals of burns and fire disasters · 2026Article
- Indocyanine green fluorescence-guided surgery in acute settings: state-of-the art.Frontiers in surgery · 2026Review
- Assessing detector stability and image quality of thermal cameras on smartphones for medical applications: a comparative study.Medical & biological engineering & computing · 2025Article
- Indocyanine green angiography processing and analysis pipeline for the assessment of indeterminate burn wounds.Journal of biomedical optics · 2025Article
- Strategies for Optimizing Acute Burn Wound Therapy: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2025Review
- Utility of indocyanine green fluorescent dye in emergency general surgery: a review of the contemporary literature.Frontiers in surgery · 2024Review
- Bedside Fluorescence Microangiography for Frostbite Diagnosis in the Emergency Department.The western journal of emergency medicine · 2022Article
- [Research advances on the techniques for diagnosing burn wound depth].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- The Role of ICG Angiography in Decision Making About Skin-Sparing in Pediatric Acute Trauma.Frontiers in pediatrics · 2022Article
- Indocyanine Green Angiography Precise Marking for Indeterminate Burn Excision: A Prospective, Multi-centered, Double-blinded Study.Plastic and reconstructive surgery. Global open · 2021Article
- An Inconvenient Truth of Clinical Assessment and Indocyanine Green Angiography Precise Marking for Indeterminate Burn Excision.Plastic and reconstructive surgery. Global open · 2021Article
- A Critical Update of the Assessment and Acute Management of Patients with Severe Burns.Advances in wound care · 2019Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical assessment of indeterminate burn wounds has been reported to yield poor accuracy, even when performed by burn experts. Indocyanine green (ICG) dye angiography has been found to be highly accurate in assessing burn depth, but there is still limited evidence of its use in indeterminate burn wounds. This study aims to compare the accuracy of ICG angiography to that of clinical assessment in assessing indeterminate burn wounds.
methodsThis is a prospective, multicentered, triple-blinded, experimental study. Participants were stable patients, admitted to the hospital with burn wounds of indeterminate depth. The burn wounds were clinically assessed by an attending plastic surgeon. ICG angiography was performed and evaluated by another surgeon. Tissue biopsies were obtained and sent for histological study to be assessed as the gold standard.
resultsIn the 30 burn sites that were assessed, the accuracy of ICG angiography was 100.0%, compared with 50.0% for clinical assessment (p < 0.001). Clinical assessment yielded a sensitivity of 33.3% and specificity of 66.7%, while ICG angiography yielded both a sensitivity and specificity of 100.0%. Therefore, the number needed to treat for using ICG angiography in indeterminate burn wounds was two.
conclusionIndocyanine green angiography yields a significantly higher accuracy than clinical assessment in indeterminate burn wounds. This intervention can, thus, be a useful tool to aid clinical judgment.
trial registrationThai Clinical Trials Registry, number TCTR20170821001. LEVEL OF EVIDENCE: Diagnostic test, level I.
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