Trial reportThe Journal of clinical investigation2019
Cingulum stimulation enhances positive affect and anxiolysis to facilitate awake craniotomy.
Trial report in The Journal of clinical investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04958096 (Adjunct Cortical Stimulation With Deep Brain Stimulation), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adjunct Cortical Stimulation With Deep Brain Stimulation (DBS) to Treat Obsessive Compulsive Disorder (OCD)
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- An update on tests used for intraoperative monitoring of cognition during awake craniotomy.Acta neurochirurgica · 2024Pooled it
- Specific tractography differences in autism compared to developmental coordination disorder.Scientific reports · 2022Trial
- ANT-DBS in epilepsy shows no effect on selected neuropsychiatric tests.Acta neurologica Scandinavica · 2022Trial
- Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Inside the frontal face network: multimodal evidence for distinct emotional and motor resonance circuits.Brain structure & function · 2026Article
- Psychometric Properties of a Novel Affective Bias Task and Its Application in Clinical and Nonclinical Populations.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.Research square · 2025Article
- Asymmetric Cingulum Bundle Connectivity Is Modulated by Paracingulate Sulcus Morphology.Human brain mapping · 2025Article
- Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation.Nature biomedical engineering · 2025Review
- Anatomo-functional basis of emotional and motor resonance elicited by facial expressions.Brain : a journal of neurology · 2024Article
- Insula uses overlapping codes for emotion in self and others.bioRxiv : the preprint server for biology · 2024Article
- Effects of transcranial magnetic stimulation on the human brain recorded with intracranial electrocorticography.Molecular psychiatry · 2024Article
- Intracranial stimulation and EEG feature analysis reveal affective salience network specialization.Brain : a journal of neurology · 2023Article
- A mesocorticolimbic signature of pleasure in the human brain.Nature human behaviour · 2023Article
- Psychophysical pain encoding in the cingulate cortex predicts responsiveness of electrical stimulation.medRxiv : the preprint server for health sciences · 2023Article
- Visceral and emotional responses to direct electrical stimulations of the cortex.Annals of clinical and translational neurology · 2023Article
- The naturalistic approach to laughter in humans and other animals: towards a unified theory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- The web of laughter: frontal and limbic projections of the anterior cingulate cortex revealed by cortico-cortical evoked potential from sites eliciting laughter.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Neurophysiological mechanisms of implicit and explicit memory in the process of consciousness.Journal of neurophysiology · 2022Review
- Postcraniotomy Headache: Etiologies and Treatments.Current pain and headache reports · 2022Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAwake neurosurgery requires patients to converse and respond to visual or verbal prompts to identify and protect brain tissue supporting essential functions such as language, primary sensory modalities, and motor function. These procedures can be poorly tolerated because of patient anxiety, yet acute anxiolytic medications typically cause sedation and impair cortical function.
methodsIn this study, direct electrical stimulation of the left dorsal anterior cingulum bundle was discovered to reliably evoke positive affect and anxiolysis without sedation in a patient with epilepsy undergoing research testing during standard inpatient intracranial electrode monitoring. These effects were quantified using subjective and objective behavioral measures, and stimulation was found to evoke robust changes in local and distant neural activity.
resultsThe index patient ultimately required an awake craniotomy procedure to confirm safe resection margins in the treatment of her epilepsy. During the procedure, cingulum bundle stimulation enhanced positive affect and reduced the patient's anxiety to the point that intravenous anesthetic/anxiolytic medications were discontinued and cognitive testing was completed. Behavioral responses were subsequently replicated in 2 patients with anatomically similar electrode placements localized to an approximately 1-cm span along the anterior dorsal cingulum bundle above genu of the corpus callosum.
conclusionsThe current study demonstrates a robust anxiolytic response to cingulum bundle stimulation in 3 patients with epilepsy.
trial registrationThe current study was not affiliated with any formal clinical trial.
fundingThis project was supported by the American Foundation for Suicide Prevention and the NIH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.