ArticleAdvanced materials (Deerfield Beach, Fla.)2019
A Biomimetic Non-Antibiotic Approach to Eradicate Drug-Resistant Infections.
Article in Advanced materials (Deerfield Beach, Fla.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review.Theranostics · 2020Pooled it
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- Glycosylated graphene-nylon fiber: A new material platform to balance the nanotoxicity and bioactivity for anti-infective therapy.Bioactive materials · 2026Article
- [In vitro and in vivo antibacterial effects of the mitochondrial antioxidant Visomitin againstZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Multifunctional Thermal-responsive Bioglue Targeted at Suppurative Infection in Oral Cavity.International dental journal · 2026Article
- Glyco-engineered multifunctional hydrogel with bacterial fishing hooks for targeted bacterial eradication and enhanced wound healing.Materials today. Bio · 2025Article
- In Vivo Evidence on the Emerging Potential of Non-Digestible Oligosaccharides as Therapeutic Agents in Bacterial and Viral Infections.Nutrients · 2025Review
- Platinum nanoparticles in cancer therapy: chemotherapeutic enhancement and ROS generation.Medical oncology (Northwood, London, England) · 2025Review
- Single Atom Engineered Antibiotics Overcome Bacterial Resistance.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Photothermal Properties of Solid-Supported Gold Nanorods.Nano letters · 2024Article
- Inhaled immunoantimicrobials for the treatment of chronic obstructive pulmonary disease.Science advances · 2024Article
- Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery.Pharmaceutics · 2024Review
- Fluoride-activated photothermal system for promoting bacteria-infected wound healing.Journal of nanobiotechnology · 2023Article
- Trends in Photothermal Nanostructures for Antimicrobial Applications.International journal of molecular sciences · 2023Review
- Neutrophil-inspired photothermo-responsive drug delivery system for targeted treatment of bacterial infection and endotoxins neutralization.Biomaterials research · 2023Article
- A Fucosylated Lactose-Presenting Tetravalent Glycocluster Acting as a Mutual Ligand ofInternational journal of molecular sciences · 2022Article
- Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening.AMB Express · 2022Article
- Hetero-Multivalent Targeted Liposomal Drug Delivery to TreatACS applied materials & interfaces · 2022Article
- Van-mediated self-aggregating photothermal agents combined with multifunctional magnetic nickel oxide nanoparticles for precise elimination of bacterial infections.Journal of nanobiotechnology · 2022Article
- NIR-activated nanosystems with self-modulated bacteria targeting for enhanced biofilm eradication and caries prevention.Bioactive materials · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The chronic infections by pathogenic Pseudomonas aeruginosa (P. aeruginosa) remain to be properly addressed. In particular, for drug-resistant strains, limited medication is available. An in vivo pneumonia model induced by a clinically isolated aminoglycoside resistant strain of P. aeruginosa is developed. Tobramycin clinically treating P. aeruginosa infections is found to be ineffective to inhibit or eliminate this drug-resistant strain. Here, a newly developed non-antibiotics based nanoformulation plus near-infrared (NIR) photothermal treatment shows a remarkable antibacterial efficacy in treating this drug-resistant pneumonia. The novel formulation contains 50-100 nm long nanorods decorated with two types of glycomimetic polymers to specifically block bacterial LecA and LecB lectins, respectively, which are essential for bacterial biofilm development. Such a 3D display of heteromultivalent glycomimetics on a large scale is inspired by the natural strengthening mechanism for the carbohydrate-lectin interaction that occurs when bacteria initially infects the host. This novel formulation shows the most efficient bacteria inhabitation and killing against P. aeruginosa infection, through lectin blocking and the near-infrared-light-induced photothermal effect of gold nanorods, respectively. Collectively, the novel biomimetic design combined with the photothermal killing capability is expected to be an alternative treatment strategy against the ever-threatening drug-resistant infectious diseases when known antibiotics have failed.
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