Evidence map›Paper›PMID 30588877›Full record

SynthesisThyroid : official journal of the American Thyroid Association2019

Association Between Diethylhexyl Phthalate Exposure and Thyroid Function: A Meta-Analysis.

Min Joo Kim, Shinje Moon, Byung-Chul Oh, Dawoon Jung, Kyungho Choi, Young Joo Park

Erratum issuedOpen access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Thyroid : official journal of the American Thyroid Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 7 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 7 syntheses or guidelines pooled it, 95 citations in OpenAlex.

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  18. EndoCompass Project: Environmental Endocrinology.Hormone research in paediatrics · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Min Joo Kim1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Shinje Moon2 Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University College of Medicine, Seoul, Republic of Korea.
Byung-Chul Oh3 Department of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Republic of Korea.
Dawoon Jung4 Division of Environmental Health, Korea Environment Institute, Sejong, Republic of Korea.
Kyungho Choi5 School of Public Health, Seoul National University, Seoul, Republic of Korea.
Young Joo Park1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Seoul National University · KRGachon University · KRHallym University · KRKorea Environment Institute · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiethylhexyl phthalate (DEHP) is widely used in industrial products, particularly as plasticizers and softeners. Because it is used extensively, DEHP has been detected in humans worldwide. Although epidemiological studies suggest that DEHP can disrupt the function of the hypothalamic-pituitary-thyroid (HPT) axis, evidence on the association between DEHP exposure and thyroid function remains inconclusive. Therefore, a comprehensive meta-analysis was performed to investigate the association between DEHP exposure and the HPT axis in humans.

methodsA literature search of the MEDLINE, EMBASE, and Web of Science databases was conducted to search for studies in which the correlation coefficient values or regression coefficient values between three major DEHP metabolites (i.e., monoethylhexyl phthalate [MEHP], mono [2-ethyl-5-hydroxyhexyl] phthalate [MEHHP], and mono [2-ethyl-5-oxohexyl] phthalate) and thyrotropin, free thyroxine (T4), or total T4 were determined. The association between DEHPs and thyroid hormone levels were evaluated using Pearson's correlation coefficients.

resultsThirteen eligible articles were included. Urinary MEHP and MEHHP concentration was negatively correlated with total T4. Pooled correlation coefficients between MEHP/MEHHP and total T4 were -0.02 [confidence interval (CI) -0.05 to 0.00] and -0.03 [CI -0.05 to -0.01], respectively. Urinary mono (2-ethyl-5-oxohexyl) phthalate concentration was positively correlated with thyrotropin, and the pooled correlation coefficient was 0.02 [CI 0.00-0.04].

conclusionsThe findings of this meta-analysis suggest a significant association between the exposure of DEHP metabolites and the function of the HPT axis.

Indexed as

Diethylhexyl PhthalateEnvironmental ExposureHumansPhthalic AcidsThyroid Function TestsThyroid GlandThyrotropinThyroxineDiethylhexyl Phthalatemono(2-ethyl-5-hydroxyhexyl) phthalatemono(2-ethyl-5-oxohexyl)phthalatemono-(2-ethylhexyl)phthalatephthalic acidPhthalic AcidsThyrotropinThyroxinediethylhexyl phthalateendocrine disruptorsthyroid hormones

Identifiers

PMID30588877
PMCPMC6488044
OpenAlexW2907103692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.