Evidence map›Paper›PMID 30588822›Full record

ArticleBrain connectivity2019

Parvalbumin Cell Ablation of NMDA-R1 Leads to Altered Phase, But Not Amplitude, of Gamma-Band Cross-Frequency Coupling.

Russell G Port, Jeffrey I Berman, Song Liu, Robert E Featherstone, Timothy P L Roberts, Steven J Siegel

Open access · greenAbstract read
In one paragraph

Article in Brain connectivity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Russell G Port1 Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Jeffrey I Berman2 Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Song Liu2 Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Robert E Featherstone3 Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.
Timothy P L Roberts2 Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Steven J Siegel3 Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.
Children's Hospital of Philadelphia · USUniversity of Southern California · US

Funding

NMDA Receptor Hypofunction in the Amygdala of Schizophrenia PatientsP50MH096891 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI HAHN, CHANG-GYU · 2012 to 2016
$10.6M
The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI SCHULTZ, ROBERT THOMAS · 2016 to 2020
$6.3M
SCHIZOPHRENIA: A NEUROPSYCHIATRIC PERSPECTIVET32MH019112 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 1990 to 2024
$6.2M
Electrophysiological Signatures of Language Impairment in Autism Spectrum DisordeR01DC008871 · NIDCD · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBERTS, TIMOTHY P · 2007 to 2018
$3.6M
Structural and Functional Neuroimaging of the Auditory System in AutismK01MH096091 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI BERMAN, JEFFREY I · 2012 to 2015
$632k
Phase-Amplitude Coupling and Dysfunction in ASDR21MH110869 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI BERMAN, JEFFREY I · 2017 to 2018
$473k
NICHD NIH HHS U54 HD086984NIDCD NIH HHS R01 DC008871NIMH NIH HHS K01 MH096091NIMH NIH HHS P50 MH096891NIMH NIH HHS R21 MH110869NIMH NIH HHS T32 MH019112
6 · The paper itself

Abstract

Altered gamma-band electrophysiological activity in individuals with autism spectrum disorder (ASD) is well documented, and analogous gamma-band alterations are recapitulated in several preclinical murine models relevant to ASD. Such gamma-band activity is hypothesized to underlie local circuit processes. Gamma-band cross-frequency coupling (CFC), a related though distinct metric, interrogates local neural circuit signal integration. Several recent studies have observed perturbed gamma-band CFC in individuals with ASD, although the direction of change remains unresolved. It also remains unclear whether murine models relevant to ASD recapitulate this altered gamma-band CFC. As such, this study examined whether mice with parvalbumin (PV) cell-specific ablation of NMDA-R1 (PV

Indexed as

AnimalsAutism Spectrum DisorderDisease Models, AnimalElectroencephalographyElectrophysiological PhenomenaGamma RhythmMagnetic Resonance ImagingMaleMiceMice, Inbred StrainsParvalbuminsReceptors, N-Methyl-D-AspartateRestParvalbuminsReceptors, N-Methyl-D-AspartateASDcross-frequency couplinggammaphasephase-amplitude coupling

Identifiers

PMID30588822
PMCPMC6479236
OpenAlexW2908246265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.