Evidence map›Paper›PMID 30588765›Full record

ArticleJournal of diabetes investigation2019

Evaluation of cellular and humoral autoimmunity before the development of type 1 diabetes in a patient with idiopathic CD4 lymphocytopenia.

Koji Maruyama, Daisuke Chujo, Koji Watanabe, Akitsu Kawabe, Takehiro Sugiyama, Mitsuru Ohsugi, Akiyo Tanabe, Kohjiro Ueki, Hiroshi Kajio

Open access · goldAbstract readCase ReportsEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Koji MaruyamaDepartment of Diabetes, Endocrinology and Metabolism, Tokyo, Japan.
Daisuke ChujoDepartment of Diabetes, Endocrinology and Metabolism, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7727-6310
Koji WatanabeAIDS Clinical Center, Tokyo, Japan.
Akitsu KawabeIslet Cell Transplantation Project, Tokyo, Japan.
Takehiro SugiyamaDiabetes and Metabolism Information Center, Tokyo, Japan.
Mitsuru OhsugiDepartment of Diabetes, Endocrinology and Metabolism, Tokyo, Japan.
Akiyo TanabeDepartment of Diabetes, Endocrinology and Metabolism, Tokyo, Japan.
Kohjiro UekiDepartment of Diabetes, Endocrinology and Metabolism, Tokyo, Japan.
Hiroshi KajioDepartment of Diabetes, Endocrinology and Metabolism, Tokyo, Japan.
Diabetes Australia · AUAIDS United · USThe Japanese Data Center for Hematopoietic Cell Transplantation · JP

Funding

Japan Diabetes FoundationJapan Society for the Promotion of Science 17K09854
6 · The paper itself

Abstract

A 64-year-old woman developed type 1 diabetes 23 years after the diagnosis of idiopathic CD4 lymphocytopenia. To investigate the etiological interaction between idiopathic CD4 lymphocytopenia and type 1 diabetes, we carried out a longitudinal analysis related to islet-specific autoimmunity. Anti-glutamic acid decarboxylase antibody had been already weakly positive for at least 16 years and started rising at 6 months before the onset of type 1 diabetes. The seroconversion of anti-insulinoma-associated antigen-2 antibody and insulin autoantibody occurred at the time of onset. The ratio of CD8/CD4 had been gradually increasing for 8 years before type 1 diabetes onset. Notably, islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD8

Indexed as

AutoimmunityBiomarkersCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDiabetes Mellitus, Type 1FemaleGlucose-6-PhosphataseHumansInsulin-Secreting CellsLongitudinal StudiesLymphopeniaMiddle AgedPrognosisBiomarkersGlucose-6-PhosphataseIdiopathic CD4 lymphocytopeniaT cellsType 1 diabetes

Identifiers

PMID30588765
PMCPMC6626996
OpenAlexW2907684650

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.