ArticleAnnals of surgical oncology2019
Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography Results in Negative Surgical Margins and Decreased Local Recurrence in an Orthotopic Mouse Model of Osteosarcoma.
Article in Annals of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04752137 (Evaluation of Intraoperative Tumor Margin Identification With Fluorescent Dye Imaging), which is not on this map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Intraoperative Tumor Margin Identification With Fluorescent Dye Imaging
Who cites it
12 citing papers in PubMed.
- Targeted Near-Infrared Photoacoustic Probes for Dual-Channel Cartilage and Bone Imaging.Angewandte Chemie (International ed. in English) · 2026Article
- Research Progress on the Evaluation and Clinical Value of Negative Surgical Margins in Osteosarcoma.Orthopedic research and reviews · 2026Review
- Children's Oncology Group's 2023 blueprint for research: Surgery.Pediatric blood & cancer · 2024Article
- Intraoperative Evaluation of Soft Tissue Sarcoma Surgical Margins with Indocyanine Green Fluorescence Imaging.Cancers · 2023Article
- Progresses in Fluorescence Imaging Guidance for Bone and Soft Tissue Sarcoma Surgery.Frontiers in oncology · 2022Review
- ASO Author Reflections: VAC Dressing in Staging Myxofibrosarcoma Resection in the Extremities: Is it Safe?Annals of surgical oncology · 2021Article
- Indocyanine Green for Leakage Control in Isolated Limb Perfusion.Journal of personalized medicine · 2021Article
- Update on Osteosarcoma.Current oncology reports · 2021Review
- Transplantation of autologous extracellular vesicles for cancer-specific targeting.Theranostics · 2021Article
- Multidisciplinary treatment of soft tissue sarcomas: An update.World journal of clinical oncology · 2020Review
- Extremity Soft Tissue Sarcoma: Role of Local Control.Current treatment options in oncology · 2020Review
- CORR® Tumor Board: Can Navigation Improve the Ability to Achieve Tumor-free Margins in Pelvic and Sacral Primary Bone Sarcoma Resections? A Historically Controlled Study.Clinical orthopaedics and related research · 2019Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundSurgical resection with negative margins is the foundation of extremity sarcoma management. Failure to achieve negative surgical margins can result in local recurrence (LR), a potentially devastating complication. Indocyanine green (ICG) is a US FDA-approved fluorophore previously used to guide carcinoma resections. We investigated the potential of ICG as an intraoperative guide during experimental sarcoma resection.
methodsFifty 6-week-old immunocompetent Balb/c female mice received left proximal tibia paraphyseal injections of 5 × 10
resultsEleven of 25 animals from each group developed gross tumors. Four weeks after resection, group 1 had 0/11 tumor recurrences, while group 2 had recurrences in 9/11 (81.8%) experimental mice (p < 0.0002) (Fig. 2). There was a 100% NPV in group 1, and no tumor recurrence with fluorescence-free margins after the primary surgery. Group 2 had a 100% positive predictive value for the development of an LR if any fluorescent signal was present at the surgical margin after resection.
conclusionIntraoperative ICG guidance led to reliably negative surgical margins and a diminished LR rate. Given the benign safety profile of ICG and its prior clinical success, these results could be immediately translatable to the clinical realm.
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