ArticleTomography (Ann Arbor, Mich.)2018
A Radiodensity Histogram Study of the Brain in Multiple Sclerosis.
Article in Tomography (Ann Arbor, Mich.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Head CT: Toward Making Full Use of the Information the X-Rays Give.AJNR. American journal of neuroradiology · 2021Review
- Quantitative signal properties from standardized MRIs correlate with multiple sclerosis disability.Annals of clinical and translational neurology · 2021Article
- The effects of the skull on CT imaging of the brain: a skull and brain phantom study.The British journal of radiology · 2021Article
- Pediatric Head CT: Automated Quantitative Analysis with Quantile Regression.AJNR. American journal of neuroradiology · 2021Article
- Aging and the Brain: A Quantitative Study of Clinical CT Images.AJNR. American journal of neuroradiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is a progressive neurodegenerative disease, affecting 1 million Americans and 2.5 million people globally. Although the diagnosis is made clinically, imaging plays a major role in diagnosing and monitoring disease progression and treatment response. Magnetic resonance imaging (MRI) has proven sensitive in imaging MS lesions, but the characterization offered by routine clinical MRI remains qualitative and with discrepancies between imaging and clinical findings. We investigated the ability of digital analysis of noncontrast head computed tomography (CT) images to detect global brain changes of MS. All routine diagnostic head CTs obtained on patients with known MS obtained from 1 of 2 scan platforms from 6/1/2011 to 6/1/2015 were reviewed. Head CT images from 54 patients with MS met inclusion criteria. Head CT images were processed and histogram metrics were compared to age- and gender- matched control subjects from the same CT scanners during the same time interval. Histogram metrics were correlated with plaque burden as seen on MRI studies. Compared with control subjects, patients had increased total brain radiodensity (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.