Evidence map›Paper›PMID 30588418›Full record

ArticleInternational journal of ophthalmology2018

Serum microRNA-221 as a biomarker for diabetic retinopathy in patients associated with type 2 diabetes.

He-Nan Liu, Xun Li, Na Wu, Meng-Meng Tong, Shuo Chen, Shan-Shan Zhu, Wei Qian, Xiao-Long Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  3. Epigenetic Mechanisms in Type 2 Diabetes Retinopathy: A Systematic Review.International journal of molecular sciences · 2021
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  15. Circulating Nucleic Acid-Based Biomarkers of Type 2 Diabetes.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

He-Nan LiuDepartment of Ophthalmology, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China.
Xun LiDepartment of Ophthalmology, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China.
Na WuDepartment of Endocrinology, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China.
Meng-Meng TongSino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang 110169, Liaoning Province, China.
Shuo ChenSino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang 110169, Liaoning Province, China.
Shan-Shan ZhuSino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang 110169, Liaoning Province, China.
Wei QianSino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang 110169, Liaoning Province, China.
Xiao-Long ChenDepartment of Ophthalmology, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China.
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the candidate microRNA (miRNA), miR-221 as a novel biomarker for diabetic retinopathy (DR) in patients associated with type 2 diabetes (T2D).

methodsThe subjects involved were divided into four groups: healthy control (HC), no diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) group. Serum miR-221 was validated by real-time quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Also, serum angiotensin II (Ang II) and vascular endothelial growth factor (VEGF) were examined by enzyme-linked immunosorbent assay. In addition, receiver operating characteristic (ROC) curve was performed to explore the diagnostic accuracy of miR-221, Ang II and VEGF for DR in patients with T2D. Spearman's rank correlation coefficient was executed to estimate the correlations of serum miR-221 with metabolic parameters and serum markers in patients with T2D.

resultsPrimarily, serum miR-221, Ang II and VEGF were increased significantly in T2D patients compared to HC participant respectively, and progressive up-regulated in NDR, NPDR and PDR groups (

conclusionSerum miR-221 as a potential biomarker could be related to not only occurrence but also progression for DR in patients with T2D. However, a prospective clinical trial is warranted.

Indexed as

biomarkerdiabetic retinopathymicroRNA-221type 2 diabetes

Identifiers

PMID30588418
PMCPMC6288522
OpenAlexW2912276967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.